氟尼辛葡甲胺注射液对靶动物奶牛的安全性研究

Study on the Target Animal Safety of Flunixin Meglumine on Dairy Cattle

为研究氟尼辛葡甲胺注射液对靶动物奶牛的安全性,选择20头健康泌乳奶牛,随机分成4组,即1×(2.2 mg/kg bw)、3×(6.6 mg/kg bw)、5×(11.0 mg/kg bw)推荐剂量组,空白对照组(注射无菌注射用水)。静脉注射给药每日1次,连续给药7 d,观察用药后奶牛的直肠温度、精神状态以及乳房局部症状等临床症状,并进行血液生理和血清生化指标的测定。结果显示,1×、3×推荐剂量组临床观察未发现明显的不良反应,血液生理、生化指标检测结果均在正常范围内,表明氟尼辛葡甲胺注射液在临床上用于靶动物奶牛是安全的。

The aim of the experiment was to evaluate the safety of flunixin meglumine injection on dairy cows.Twenty healthy lactating dairy cows were selected in this experiment and divided into 4 groups randomly： the recommended dosage(2.2 mg/kg bw）,three times of recommended dosage(6.6 mg/kg bw） group、five times of recommended dosage(11.0 mg/kg bw）,the negative control. Each group was treated once a day by intravenous injection for seven days. During the experiment,rectal temperature,mental attitude,local reaction of the udder,hematology and serum chemistries of the dairy cows were undertaken. The result shows that the clinical symptoms of animals in the 1×,3 ×dose level were normal,the hematology and serum chemistry index in the normal range.The flunixin meglumine injection is safe to dairy cow.