放射线敏感性调节信号通路在肿瘤治疗中的研究进展

Progress of signaling pathways regulating the sensitivity of irradiation in cancer therapy

放疗具有非入侵性和局部、低毒性的特点使其成为晚期非手术性癌症治疗的标准方法之一，由于癌细胞的先天或者获得性对放疗产生的抗性严重影响了治疗效果。肿瘤细胞内的各种抗凋亡信号通路和（或）蛋白异常激活在这种放疗抗性中发挥决定性作用。文章综述了关键放疗敏感性调控分子如Ras、类胰岛素生长因子1型受体、转化生长因子-β、组蛋白去乙酰化酶和热休克蛋白90在肿瘤治疗中的作用，以期找到提高放疗效果的潜在靶点。

Radiotherapy characterized by invasive, localization and low toxicity has been recognized as one of the standard cancer therapy regimes, especially for non-surgically resectable advanced cancers. However, inherent and acquired resistance of cancer ceils has significantly impeded the efficacy ofradiotherapy. Of all the resistance determinants, varieties of anti-apoptotic signaling pathways or anti-survival proteins aberrant activation in malignant tumor cells play crucial roles in radiation insensitivity. This paper mainly focuses on clarifying the roles of the interesting key molecular signals including Ras, insulin-like growth factor type 1 receptor, transforming growth factor-beta, histone deacetylase and heat shock protein 90 in regulating radiotherapy sensitivity, in order to find the potential targets to improve the efficacy of radiotherapy.