自分泌运动因子在肿瘤中的研究进展

Progress of autotaxin in tumors

自分泌运动因子（ATX）是磷脂信号通路的关键酶，属于胞外焦磷酸酶/磷酸二酯酶（ENPP）家族的一员，具有溶血磷脂酶D的活性。ATX在多种肿瘤细胞中高表达，在肿瘤的发生、发展尤其是促进肿瘤细胞转移过程中发挥着重要作用。近年来还发现ATX与肿瘤的耐药性及血管生成相关。随着ATX更多功能被发现，其在肿瘤生物学研究领域会受到越来越多关注。文章对ATX在恶性肿瘤中的最新研究进展进行综述。

Autotaxin （ATX） as a member of nucleotide pyrophosphatase/phosphodiesterase （ENPP） family, possesses the activity of lysophospholipase D, and plays a key role in lipid signaling pathway.Increased ATX expression has been detected in a large variety of cancers,implying its important functions in tumor origination and development, especially tumor metastasis. Moreover, ATX has been shown to contribute to drug resistance and angiogenesis. ATX emerges as an attractive target in tumor biology due to its multiple activities in tumor biology. This review summarizes the current progress of ATX in tumors.