银杏二萜内酯有效部位(GA,GB,GK)配伍活性研究

Effect of compatibility of ginkgolide A,ginkgolide B and ginkgolide K

研究银杏二萜内酯（ginkgolide）A,B,K（GA,GB,GK）最佳活性配伍。比较化合物GA,GB,GK单用,两两配伍及三者配伍对PAF诱导的血小板聚集活性及大鼠脑缺血再灌注模型（tMCAO）的影响。GA,GB,GK不同配伍均可明显降低血小板活化因子（platelet-activating,PAF）诱导的血小板聚集的最大聚集率,其中三者联用抑制率最高;GA,GB,GK不同配伍对大鼠tMCAO模型的神经功能,脑梗死体积和脑水肿有不同程度的减轻,其作用强弱为三者组合大于两两配伍及单用。GA,GB,GK三者联用抗血小板聚集及改善tMCAO大鼠引起的神经损伤的作用最强。

To investigate the best active compatibility of ginkgolide A,B and K（ GA,GB,GK）. The effects of GA,GB,GK alone,combinations of each two of them,and combinations of these three components on platelet-activating factor（ PAF）-induced platelet aggregation activity and rat cerebral ischemia reperfusion model（ tMCAO） were compared in this study. Different compatibilities of GA,GB and GK could significantly reduce the maximum aggregation rate of PAF-induced platelet aggregation,and the effect was most obvious in combination of the three. Different compatibilities of GA,GB and GK could alleviate the neural function,cerebral infarction volume and cerebral edema in the tMCAO model of rats to different degrees,and the effect of combinations of the three was stronger than those of combinations of two and single use. The combination of all of GA,GB and GK had the strongest effect on nerve injury caused by anti-platelet aggregation in tMCAO rats.