台湾狗牙花枝叶的生物碱类成分研究

Studies on alkaloids from Ervatamia pandacaqui

对台湾狗牙花的生物碱类成分进行研究。采用硅胶、Sephadex LH-20、ODS、高效制备液相等柱色谱方法,对台湾狗牙花枝叶的总生物碱进行分离和纯化,并利用UV,IR,MS,NMR等各种波谱技术方法鉴定化合物的结构。从中分离鉴定了11个生物碱类化合物,分别为coronaridine（1）,3-oxocoronaridine（2）,19S-heyneanine（3）,19R-heyneanine（4）,voacangine（5）,3-oxovoacangine（6）,voacristine（7）,19-epi-voacristine（8）,iso-voacangine（9）,coronaridine 7-hydroxyindolenine（10）,voacangine 7-hydroxyindolenine（11）。化合物1-11均仅为首次从该植物中分离得到。

To inverstigate the alkaloids from the twigs and leaves of Ervatamia pandacaqui,eleven known alkaloids were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,as well as RP-HPLC. Their structures were elucidated by UV,IR,MS,and NMR spectral data as coronaridine（ 1）,3-oxocoronaridine（ 2）,19 S-heyneanine（ 3）,19 R-heyneanine（ 4）,voacangine（ 5）,3-oxovoacangine（ 6）,voacristine（ 7）,19-epi-voacristine（ 8）,iso-voacangine（ 9）,coronaridine 7-hydroxyindolenine（ 10）,and voacangine 7-hydroxyindolenine（ 11）. Compounds 1-11 were isolated from E. pandacaqui for the first time.