摘要
目的评价益气活血方药治疗血管性痴呆的疗效和安全性。方法利用计算机检索中国生物医学文献数据库、中国知网、万方数据库与维普数据库,检索时间均从建库至2017年6月,查找研究方案为随机对照实验(RCT),干预措施为益气活血方药治疗血管性痴呆且已发表的较高质量文献。采用Rav Man 5.3.5软件进行Meta分析。结果最终纳入的RCT 21篇,共1716例血管性痴呆患者。结果显示:益气活血方药联合西药治疗血管性痴呆总体临床疗效与单纯西药治疗比较,其差异有统计学意义[OR=2.69,95%CI(2.15,3.37),P<0.00001];益气活血方药联合西药治疗血管性痴呆的MMSE评分与单纯西药治疗比较,差异有统计学意义[MD=2.68,95%CI(2.32,3.03),P<0.00001];益气活血方药联合西药常规治疗血管性痴呆的HDS评分与单纯西药常规治疗比较,差异有统计学意义[MD=4.56,95%CI(4.32,4.81),P<0.00001];治疗过程中未见明显不良反应。结论现有的证据表明益气活血方或益气活血方药联合西药治疗血管性痴呆的临床疗效优于单纯西药治疗,且能延缓精神状态与智力的损伤。
Objective To evaluate the efficacy and safety of clinical research studies of replenishing qi and activating blood prescription in the treatment of vascular dementia. Methods CBM, CNKI, VIP and Wanfang database were electronically searched for randomized controlled trials( RCTs) on replenishing qi and activating blood prescription in the treatment of vascular dementia( from June 1994 to June 2017). Two reviewers independently screened literature according to the inclusion and exclusion criteria,and meta-analyses were performed by using Rev Man5.3.5 software. Results The results of meta-analysis indicated replenishing qi and activating blood prescription combined with western medicine had significant differences in the effective rate for vascular dementia compared with single western medicine routine treatment [ OR =2.69, 95% CI( 2.15, 3.37), P〈0.00001], and it had significant differences in treating the mini-mental state examination compared with single western medicine routine treatment [MD=2.68, 95% CI( 2.32, 3.03), P〈0.00001]. In addition, replenishing qi and activating blood prescription combined with western medicine was superior to single western medicine routine treatment [MD=4.56, 95%CI(4.32, 4.81), P〈0.00001] in improving the Hasegawa dementia scale. Adverse reaction and event was slight in research report. Conclusion The existed limited evidences suggest replenishing qi and activating blood prescription combined with western medicine is quite effective in treating vascular dementia, it also can improve the mini-mental state examination and Hasegawa dementia scale.
作者
易亚乔
方锐
刘林
成绍武
王国佐
廖君
陈俊炜
林勇
葛金文
YI Yaqiao;FANG Rui;LIU Lin;CHENG Shaowu;WANG Guozuo;LIAO Jun;CHEN Junwei;LIN Yong;GE Jinwen(Department of Zhongjing Theory, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;Medical College, Hangzhou Normal University, Zhejiang Province, Hangzhou 310018, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;Key Discipline of Basis of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;i. College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, Chin)
出处
《中国中医药现代远程教育》
2018年第8期47-51,共5页
Chinese Medicine Modern Distance Education of China
基金
国家自然科学基金项目【No.81603604】
湖南省重点研发计划项目【No.2017SK2111】
湖南省自然科学基金项目【No.2016JJ4064】
湖南省中医药科研计划项目【No.201594,201785】
湖南中医药大学大学生研究性学习和创新性实验计划项目
关键词
血管性痴呆
益气活血方
META分析
随机对照试验
呆证
文献研究
vascular dementia
replenishing qi and activating blood prescription
Meta analysis
randomized controlled trial
dementia
literature research