帕罗西汀联合低频脉冲治疗仪治疗早泄的临床疗效

Clinical efficacy of paroxetine combined with low-frequency pulse acupoint stimulation for premature ejaculation

目的:探讨帕罗西汀联合低频脉冲治疗早泄的临床疗效。方法:选取90例符合早泄诊断标准患者为研究对象,随机分为帕罗西汀联合低频脉冲治疗组(研究组),单独帕罗西汀药物治疗组(对照组I)和低频脉冲治疗组(对照组Ⅱ),每组30例,治疗8周,记录各组治疗前后的阴道内射精潜伏期(IELT),早泄诊断量表(PEDT)评分。对比分析3组患者治疗前后的IELT和PEDT评分,比较3组治疗的显效率。结果:研究组,对照1组,对照2组治疗前IELT分别为(1.83±0.35),(1.76±0.28),(1.85±0.31)分钟,治疗后分别延长为(6.48±0.13),(4.54±0.1),(3.56±0.21)分钟(P<0.05)。PEDT治疗前分别为(15.5±2.4),(15.6±2.3),(15.2±2.6)分,经治疗后分别降为(7.6±2.5),(9.5±2.4),(10.2±2.1)分,其差异具有统计学意义(P<0.05)。显效率分别为83%、67%、53%(P<0.05)。结论:帕罗西汀联合低频脉冲治疗早泄比单独帕罗西汀药物治疗所取得的临床疗效更好。

Objective： To investigate the clinical value of paroxetine combined with low-frequency pulse acupoint stimulation in the treatment of premature ejaculation（ PE）. Methods： 90 PE patients were equally assigned to oral paroxetine group（ 20 mg/d）,low-frequency pulse acupoint stimulation group,and combination group（ oral paroxetine 20 mg/d combined with low-frequencypulse acupoint stimulation）,all for 8 weeks. The intravaginal ejaculation latency time（ IELT） and premature ejaculation diagnostic tool（ PEDT） scores of the patients before and after treatment were obtained. Results： IELT of the three groups before treatment were（ 1. 83 ± 0. 35）,（ 1. 76 ±0. 28） and（ 1. 85 ± 0. 31） min. After treatment,they were（ 6. 48 ± 0. 13）,（ 4. 54 ± 0. 1） and（ 3. 56 ± 0. 21） min（ P〈0. 05）. PEDT of the three groups before treatment were（ 15. 5 ± 2. 4）,（ 15. 6 ± 2. 3） and（ 15. 2 ± 2. 6） and after treatment,they were（ 7. 6 ± 2. 5）,（ 9. 5 ± 2. 4） and（ 10. 2 ± 2. 1）（ P〈0. 05,with marked improvement ratesof83%,67% and53% respectively（ P〈0. 05）. Conclusions： Oral paroxetine combined with low-frequency pulse acupoint stimulation has a higher efficacy than either paroxetine or low-frequency pulse acupoint stimulation alone in the treatment of PE.