基于磁共振T1成像的帕金森病相关脑结构体积差异性分析

Differential analysis of brain structure volume associated with Parkinson's disease based on nuclear magnetic resonance T1 imaging

目的应用3.0T磁共振T1成像分析帕金森病(PD)患者脑结构如尾状核、壳核、苍白球、中脑、背侧丘脑、海马、杏仁核体积的变化,探讨MRI体积测量在PD引起形态学改变的应用及在早期诊断上的意义。方法采用3.0T MRI对40例早中期PD患者和年龄匹配的32名正常人进行扫描,分别测量出全脑体积、双侧尾状核、双侧壳核、双侧苍白球、中脑、双侧背侧丘脑、双侧海马、双侧杏仁核的体积,对体积值标准化处理后,使用SPSS22.0软件对数据进行统计学分析。结果比较早中期PD患者和正常对照组发现,PD患者的全脑、双侧尾状核、双侧海马、双侧杏仁核的标准化体积和正常人比较差异无显著性(P>0.05);双侧壳核、双侧苍白球、双侧背侧丘脑、中脑标准化体积差异有显著性(P<0.05)。结论基于MRI测量尾状核、壳核、苍白球、中脑、背侧丘脑、海马与杏仁核的体积的变化能为PD的辅助诊断提供一定帮助。

Objective To investigate the significance of MRI volume measurement in the morphological changes caused by Parkinson＇ s disease （PD） and its application in early diagnosis. The volume changes of caudate nucleus, putamen, globus pallidus, midbrain, dorsal thalamus, hippocampus and amygdala in patients with Parkinson＇ s disease were analyzed based on 3.0T MRI. Methods 3.0T MRI scans were performed in 40 patients with early and intermediate Parkinson＇ s disease （PD group） and 32 age-matched normal control subjects （NC group） , respectively. The total brain, bilateral caudate nucleus, bilateral putamen, bilateral globus pallidus, midbrain, bilateral dorsal thalamus, bilateral hippocampus and bilateral amygdala, were manually delineated by the software of ITK-snap, and their volumes were calculated and normalized respectively. SPSS was used to compare and analyze the differences between the PD group and the NC group. Results There was no difference in the volume of the whole brain between the PD and the NC （P 〉 O. 05 ）. There were significant differences in the standardized volume of the bilateral putamen, bilateral globus pallidus, bilateral dorsal thalamus, and midbrain （P 〈 0. 05 ） , but there were no differences in the standardized volume of bilateral caudate nucleus, bilateral hippocampus and bilateral amygdale （P 〉 0.05 ）. Conclusion MRI volume measurement of the change of caudate nucleus, putamen, globus pallidus, midbrain, dorsal thalamus, hippocampus and amygdala in patients with PD can be helpful for the diagnosis of Parkinson＇ s disease.