硫化氢在糖尿病微血管疾病中的作用研究进展

Research progress on the role of hydrogen sulfide in diabetic microvascular disease

作为继一氧化氮和一氧化碳之后新发现的气体信号分子,硫化氢（H2S）已引起国内外专家学者的广泛关注,并进行了大量生理学与病理生理学方面的研究。绝大多数学者认为H2S对糖尿病及其微血管病变的发生发展起着重要作用。然而,到目前为止,人体中H2S的生理功能和毒性作用仍不完全清楚,H2S效应的大部分作用机制尚未完全阐明。本文就H2S对3种常见的糖尿病微血管病变（糖尿病视网膜病变、糖尿病神经病变、糖尿病肾病）的作用及其机制研究进展作一综述,以期为糖尿病微血管病变的研究和治疗提供新的理论依据。

As a newly discovered gas signal molecule after nitric oxide and carbon monoxide,hydrogen sulfide（ H2 S）has attracted wide attention from experts and scholars both at home and abroad,and has been carried out a lot of physiological and pathophysiological studies. Most scholars believe that H2 S plays an important role in the development of diabetes and its microvascular disease. However,so far,the physiological and toxic effects of H2 S in the human body are not completely clear,and most of the mechanisms of the H2 S effect have not been fully elucidated. This paper reviews the role and mechanism of H2 S in 3 common diabetic microangiopathy（ diabetic retinopathy,diabetic neuropathy and diabetic nephropathy）,in order to provide a new theoretical basis for the research and treatment of diabetic microangiopathy.