颈动脉粥样硬化影响内皮祖细胞功能的研究进展

Research progress on the effect of carotid atherosclerosis on endothelial progenitor cell function

动脉粥样硬化是威胁人类健康的最严重的心脑血管疾病之一,阐明动脉粥样硬化发生机制和防治动脉粥样硬化已成为医学界研究的热点。颈动脉粥样硬化在一定程度上可反映全身动脉粥样硬化斑块发展状况,由于颈动脉位置表浅,易于探及检查,已被证实可作为了解和评估全身动脉粥样硬化的＂窗口＂。经研究证实,内皮祖细胞可修复受损内膜,延缓动脉粥样硬化的发生发展。本文针对颈动脉粥样硬化患者内皮祖细胞数量和功能的变化,以及内皮祖细胞对该病发生发展的作用进行概括和总结,为动脉粥样硬化的治疗与防治提供新的策略。

Atherosclerosis is one of the most serious cardiovascular and cerebrovascular diseases threatening human health. It has become a hot topic of medical research to elucidate the mechanism of atherosclerosis and prevent atherosclerosis. Carotid atherosclerosis can reflect the whole body atherosclerosis plaque development in a certain extent,the location of the carotid artery is shallow,and it is easy to detect and examine,which has been proved to be a ＂ window＂ to understand and evaluate the whole body atherosclerosis. Confirmed by research,endothelial progenitor cells can repair the damaged endometrium,delay the development of atherosclerosis. In this paper,the number and function of endothelial progenitor cells in patients with carotid atherosclerosis and the role of endothelial progenitor cells in the development of the disease are generalized and summarized,providing new strategies for the treatment and prevention of atherosclerosis.