13种中草药对申克孢子丝菌抑菌实验研究

Experimental Study of the Inhibition Effects of Thirteen Kinds of Traditional Chinese Medicine on the Sporothrix Schenckii

目的：在马齿苋等13种中草药中,观察筛选出对申克孢子丝菌有抑制作用的中草药。方法：通过微量液基稀释法,测定各药液对申克孢子丝菌的抑制作用。结果：最小抑菌浓度（MIC）由小到大排列分别为：黄连MIC 183.47μg/m L、黄柏MIC 273.07μg/m L、蛇床子MIC 512.00μg/m L、苦参MIC 546.13μg/m L、马齿苋MIC 563.20μg/m L、丹参MIC 1058.13μg/m L、金银花MIC 1297.07μg/m L、陈皮MIC 1433.60μg/m L、地榆MIC 1638.40μg/m L。来源皮肤固定型的菌株与来源皮肤淋巴管型菌株相比MIC值差异无统计学意义。结论：黄连、黄柏、蛇床子、苦参、马齿苋有较强地抑制申克孢子丝菌的作用,可以为临床治疗提供依据。

Objective：To observe the inhibitory effect of Chinese herbal medicine in 13 kinds of Chinese herbs such as purslane. Methods：To determine the inhibitory effect of various liquid drugs on Sporothrix schenckii. Results：The minimum inhibitory concentration（MIC）was arranged from small to large,including：Rhizoma Coptidis MIC 183.47 μg/m L,Cortex Phellodendri MIC 273.07 μg/m L,Cnidium Monnieri MIC 512.00 μg/m L,Sophora MIC 546.13 μg/m L,purslane MIC 563.20 μg/m L,Salvia Miltiorrhiza MIC 1058.13 μg/m L,Honeysuckle MIC 1297.07 μg/m L,orange peel MIC 1433.60 μg/m L,Sanguisorba MIC 1638.40 μg/m L. There was no statistically significant difference between the source skin type and the source skin lymphatic strain compared with the MIC. Conclusion：Rhizoma Coptidis,Cortex Phellodendri,Cnidium Monnieri,Sophora and purslane have a strong effect on the effect of Sporothrix schenckii and provide the basis for clinical treatment.