西黄丸治疗血瘀型癌性发热疗效观察

Curative Effect Observation of Xihuang Pill in the Treatment of Blood Stasis Type Cancerous Fever

目的：探讨西黄丸治疗血瘀型癌性发热的临床疗效。方法：选择2015年6月—2016年11月我院收治的血瘀型癌性发热的肿瘤患者82例,按照随机数字表法,将患者分为对照组和研究组,每组各41例。对照组患者给予肛塞吲哚美辛栓进行治疗,而研究组患者在对照组基础上联合使用西黄丸进行治疗。两组患者的疗程均为8周。治疗后,统计两组患者的总体退热疗效,分别于治疗前后,比较两组患者的体温、白细胞计数、卡氏评分（KPS）、证候积分及生活质量的变化情况,另外对比两组患者治疗期间不良反应的发生率。结果：研究组患者总体退热总有效率为92.68%（38/41）,明显高于对照组的73.17%（30/41）（χ2=5.513,P=0.019）;治疗后,研究组患者KPS和生活质量评分明显高于对照组（P〈0.05）,而证候积分显著低于对照组（P〈0.05）;对照组患者不良反应发生率为14.63%（6/41）,而研究组患者不良反应发生率为7.32%（3/41）,两组患者不良反应发生率之间的差异无统计学意义（χ2=1.123,P=0.289）。结论：西黄丸治疗血瘀型癌性发热的临床疗效显著,能够有效改善临床症状,提高生活质量,并且临床的安全性高,值得在临床上推广应用。

Objective：To evaluate the clinical efficacy of Xihuang Pill in the treatment of blood stasis type cancerous fever. Methods：According to the random indicator method,82 cases of patients with blood stasis type cancerous fever in our hospital from June 2015 to November 2016 were divided into control group and research group with 41 cases in each group. The patients in the control group were treated with indomethacin suppositories,while the patients in the research group were treated with Xihuang Pill on the base of control group. The treatment course of two groups was eight weeks. After treatment,the overall antifebrile effect of two groups of patients was counted. The change of patients＇ body temperature,antifebrile in cartesian ratings,syndrome integral,white blood cell count,and the change of quality of life was compared before and after treatment respectively. The incidence of adverse reactions of two groups of patients was compared during treatment. Results：The overall total effective rate of research group was 92.68%（38/41）,which was significantly higher than the control group [73.17%（30/41）]（χ2=5.513,P=5.513）. After treatment,The KPS and quality of life score of the research group were significantly higher than the control group（P〈0.05）,while syndrome integral of the research group were significantly lower than the control group（P〈0.05）;The incidence of adverse reactions of control group was 14.63%（6/41）,while the incidence of adverse reactions of research group was 7.32%（3/41）,which the differences between the two groups had no statistical significance（χ2=1.123,P=0.289）. Conclusion：The clinical curative effect of Xihuang Pill in the treatment of blood stasis type cancerous fever is distinct. It can effectively improve symptom,at the same time it can enhance the quality of life. It has high safety,which is worth popularization and application in clinic.