肝硬化相关胃肠动力障碍研究进展

Research progress on liver cirrhosis related gastrointestinal dysmotility

胃肠动力障碍是肝硬化常见的并发症。笔者通过查阅近年来的相关文献发现,肝硬化所导致的胃肠动力障碍可能主要涉及到胃肠Cajal间质细胞(ICCs)、脑肠肽(BGP)、胃肠电活动(GEA)和胃肠神经(GN)等方面的机制。但目前在临床上,对于肝硬化相关的胃肠动力障碍的治疗,大多是在主要治疗肝硬化本病的同时,缓解患者因胃肠动力减弱而出现的一些不适。由于其机制的复杂,对肝硬化相关的胃肠动力障碍的治疗并无统一的治疗方案。笔者据此作一综述,希冀为后续的研究和优化治疗提供参考。

Gastrointestinal dysmotility is a common complication of liver cirrhosis. Through investigating the relevant literatures in recent years, we found that the mechanism of gastrointestinal dysmotility caused by liver cirrhosis may involve interstitial cells of Cajal（ICCs）, brain gut peptide（BGP）, gastrointestinal electric activity（GEA） and gastrointestinal nerve（GN）, But at present, the main focus is put on the treatment of liver cirrhosis, along with relieving the discomfort resulted by gastrointestinal dysmotility. Because of its complex mechanism, there is no uniform treatment for gastrointestinal dysmotility related with cirrhotic. Based on the above, we hope this review can provide references for the consequent study and moreoptimal treatment.