透明质酸在皮肤科的应用

Topical hyaluronic acid in the treatment of skin diseases

透明质酸(HA)是一种存在于人体基质内的多聚糖,临床应用广泛,HA具有较高的生物相容性,增加了药物在皮损部位的停留时间;HA具有组织修复作用,缩短了伤口的愈合时间;HA对皮肤的屏障修复和炎症的调节也有一定作用。本文对HA的理化性质、生物性质和外用透明质酸在皮肤科的临床应用进行综述。

The glycosaminoglycan hyaluronic acid（ HA） is a major component of extracellular matrix,which has widely been used in clinics. HA has a good biocompatibility and increases the residence time of other agents. HA can improve the rehabilitation and reduce the cure time of wound. HA also plays an important role in the barrier therapy and regulating the activity of inflammation. The physicochemical properties,biological properties and the clinical topical application of HA in dermatology are reviewed in this article.