紫杉醇靶向化疗对小细胞肺癌的临床治疗价值和安全性

Clinical Value and Safety of Paclitaxel Targeted Chemotherapy for Small Cell Lung Cancer

目的探索紫杉醇靶向化疗对小细胞肺癌患者的临床疗效和不良反应。方法选取78例肺癌患者,随机分为观察组(39例)和对照组(39例)。观察组采用紫杉醇药物靶向化疗,对照组采用PE化疗方案,2组疗程均为3周。评价2组治疗前后胸部X成像、NSE,治疗后评价2组患者的生活质量和不良反应。结果观察组和对照组的肿瘤在不同程度上得到缓解,缓解率观察组为68.31%,高于对照组59.41%,差异无统计学意义(P>0.05)。2组治疗后NSE值均较治疗前降低,且观察组降低的程度高于对照组,差异具有统计学意义(P<0.05)。观察组生活质量良好率为79.5%,明显高于对照组的56.4%,差异有统计学意义(P<0.05)。观察组患者出现骨髓抑制、神经毒性、肝毒性和消化道等不良反应的概率分别为5.1%、2.6%、7.7%、0.0%,低于对照组的20.5%、17.9%、25.6%、7.7%,差异有统计学意义(P<0.05);观察组总不良反应率(12.8%)低于对照组(35.9%),差异具有统计学意义(P<0.05)。结论紫杉醇靶向化疗治疗小细胞肺癌具有高疗效、低药物毒性的优势,保证了患者治疗后的生存质量,也提供了快捷便利的治疗方式,值得推广。

Objective To explore the clinical efficacy and adverse reactions of paclitaxel targeted chemotherapy for patients with small cell lung cancer. Methods 78 cases of patients with lung cancer,and randomly divided into the observation group（ 39 cases） and the control group（ 39 cases） were selected,the observation group received targeted chemotherapy drug taxol,the control group received PE chemotherapy regimens,a course of 3 weeks,before and after treatment chest X-ray imaging and NSE of the 2 groups were evaluated. Quality of life and adverse reactions of the 2 groups after treatment were detected. Results The tumor in the observation group and the control group were alleviated to some extent,the remission rate was 68. 31% in the observation group and 59. 41% in the control group,the difference was not statistically significant（ P 〉 0. 05）. The NSE values of the 2 groups were lower than those before the treatment,and the degree of decrease in the observation group was higher than that of the control group,the difference was statistically significant（ P 〈 0. 05）. The good quality of life in the observation group was79. 5%,higher than 56. 4% in the control group,and the difference was statistically significant（ P 〈 0. 05）. The probability of adverse reactions of the observation group such as bone marrow suppression,neurotoxicity,hepatotoxicity and digestive tract were5. 1%,2. 6%,7. 7%,0%,lower than the control group,20. 5% 、17. 9% 、25. 6%,7. 7%,the difference was statistically significant（ P 〈 0. 05）; the total adverse reaction rate of the observation group 12. 8% was less than 35. 9% in the control group,with statistically significant difference（ P 〈 0. 05）. Conclusion Taxol targeted chemotherapy in the treatment of small cell lung cancer has a unique advantage of high curative effect and low toxicity,ensuring the quality of survival after treatment and also provides a quick and convenient way of treatment,it is worth promoting.