康莱特联合XELOX方案治疗进展期胃癌患者的近期疗效及IL-2、IL-10的影响

Short-term Efficacy of Kanglaite Combined with XELOX Chemotherapy for Advanced Gastric Cancer and Effect on IL-2,IL-10

目的研究康莱特经腹腔热灌注联合XELOX方案化疗对进展期胃癌患者近期疗效及IL-2、IL-10的影响。方法选取88例进展期胃癌患者。以数字法随机分成观察组(44例)和对照组(44例)。观察组给予康莱特经腹腔热灌注联合XELOX方案化疗;对照组只给予XELOX方案化疗;比较两组患者治疗后近期疗效与IL-2及IL-10的影响。结果观察组RR为70.45%(31/44),DCR为86.36%(38/44),均显著高于对照组的31.82%(14/44),68.18%(30/44)(均P<0.05)。治疗后观察组KPS评分显著高于对照组,CEA值显著低于对照组(均P<0.05)。随访3年,观察组复发率均显著低于对照组(均P<0.05)。治疗后观察组患者IL-2水平显著低于对照组,IL-10水平显著高于对照组(均P<0.05)。结论康莱特经腹腔热灌注联合XELOX方案化疗对胃癌患者治疗疗效显著,能有效降低复发率显著改善患者术后生存质量,能有效提高患者免疫力,安全可靠,值得临床推广。

Objective To study the Short-term efficacy of Kanglaite by intraperitoneal hyperthermic perfusion combined with XELOX chemotherapy for advanced gastric cancer and effect on IL-2,IL-10. Methods 88 cases of advanced gastric cancer patients were randomly divided into the observation group（ 44 cases） and the control group（ 44 cases）. The observation group was treated by intraperitoneal hyperthermic perfusion of Kanglaite combined with XELOX chemotherapy; the control group was given XELOX chemotherapy; Recent curative effect and effect on IL-2 and IL-10 were compared of the 2 groups. Results In the observation group,RR was 70. 45%（ 31/44）,DCR 86. 36%（ 38/44）,which were significantly higher than the control group 31. 82%（ 14/44）,68. 18%（ 30/44）（ P 〈 0. 05）. After treatment,KPS scores in the observation group was significantly higher than the control group,CEA was significantly lower than that of the control group（ P 〈 0. 05）. During 3 years of follow-up,the recurrence rate of the observation group was significantly lower than the control group（ P 〈 0. 05）. After treatment,IL-2 in the observation group was significantly lower than the control group,IL-10 was significantly higher than the control group（ all P 〈 0. 05）. Conclusion Kanglaite by intraperitoneal hyperthermic perfusion combined with XELOX chemotherapy has significant therapeutic effect for patients with gastric cancer,can effectively reduce the recurrence rate,significantly improve postoperative quality of life,effectively improve the immunity of patients,it is safe and reliable,and it is worthy of promotion.