胆红素吸附在肝衰竭挽救性治疗中的应用

The application of bilirubin adsorption in the salvage therapy of hepatic failure

急性肝衰竭病死率高，其导致的高胆红素血症往往加重多器官功能衰竭及死亡。胆红素吸附治疗既能特异性清除体内大量胆红素，又能重复使用自身的血浆和白蛋白，减少过敏反应。胆红素吸附材料采用吸附树脂及高分子吸附剂，可在肝衰竭挽救性治疗中达到更佳疗效，提高患者存活率。国内儿童肝衰竭应用胆红素吸附较少，宜进行多中心临床合作研究评价疗效。

Acute liver failure has a high mortality and leads to hyperbilirubinemia which could process to multiple organ failure and death. The bilirubin adsorption treatment can specifically remove a large amount of bilirubin in the body and can reuse own plasma and albumin to reduce allergic reactions. Bilirubin adsorbent materials including adsorbent resin and polymer adsorbent, show better effects in liver failure. Bili- rubin adsorption is used less in pediatric acute liver failure in domestic,it needs to perform multi-center clini- cal cooperative research to evaluate the response.