间充质干细胞治疗支气管肺发育不良的研究进展

Progress on mesenchymal stem cells in the treatment of bronchopulmonary dysplasia

影响早产儿的慢性肺部疾病支气管肺发育不良（bronchopulmonary dysplasia，BPD）是引起早产儿死亡和长期处于疾病状态的主要原因。目前尚未有任何有效的BPD治疗或预防策略。近年来干细胞的研究提示其可能会减轻BPD的严重程度，为BPD的治疗带来新的曙光。本综述总结了干细胞治疗BPD研究的最新进展，重点关注使用干细胞移植改善新生儿BPD动物模型肺损伤的临床前数据，这些研究提供了移植最佳干细胞类型、最佳时机、移植对象、移植途径和剂量的数据和安全问题，还讨论了BPD干细胞治疗成功的Ⅰ期临床试验结果，以及随访2年的情况。

Although some progress has been made in neonatal intensive care units for bronchopulmo- nary dysplasia （BPD）, a chronic lung disease threatening the premature, it is still the main cause of premature death and long-term illness. There is no effective treatment or prevention strategy for BPD. In recent years, ac- cording to researches, it＇s suggested that mesenchymal stem cell therapy may reduce the severity of BPD, which is a new strategy for the treatment of BPD. The review summarized the latest advances on stem cell therapy for BPD. In this regard, it focused on preclinical data of using stem cell transplantation to improve the lung injury in neonatal BPD animal models. These studies provided data and safety issues of the best stem cell types ,the best time, transplantation object, transplantation path and dose. In addition, it also discussed successful phase I clinical trial results of BPD stem cells therapy, and the follow-up condition in the next 2 years.