摘要
Central nervous system（CNS）injuries remain a leading cause of functional disabilities worldwide,often resulting in permanent neurological impairments,due to the inability to repair and regenerate damaged connections.A major contributing factor to this loss of regenerative capacity is the formation of glial scar tissue（Cregg et al.,2014）,traditionally regarded as a potent mechanical and molecular barrier to repair.
Central nervous system（CNS）injuries remain a leading cause of functional disabilities worldwide,often resulting in permanent neurological impairments,due to the inability to repair and regenerate damaged connections.A major contributing factor to this loss of regenerative capacity is the formation of glial scar tissue（Cregg et al.,2014）,traditionally regarded as a potent mechanical and molecular barrier to repair.
基金
supported by the National Health and Medical Research Council(NHMRC
APP20140228)
the Australian Research Council SRI Stem Cells Australia
supported by the State Government of Victoria and the Australian Government
supported by an NHMRC Senior Research Fellowship(APP1077677)
