宁夏部分地区碘营养水平与甲状腺疾病的相关性研究

Study on the correlation between iodine nutrition level and thyroid diseases in some areas of Ningxia

目的了解宁夏部分地区人群碘营养状况与甲状腺疾病的相关性。方法对宁夏银川市兴庆区及固原市泾源县2827例成人进行体格检查、问卷调查，并测定尿碘水平、甲状腺功能、甲状腺相关抗体和甲状腺B超。结果所有对象尿碘中位数是258．7（76．6-l506．4）μg／L，农村地区尿碘[203．3（64．6-1154）μg／L]平均水平较城市低[340．7（114．8-l726．1）μg／L，Z=19．514，P〈0．01]。65岁以上人群组的尿碘中位数水平较65岁以下人群偏低[234．2（58．9-2285．4）μg／L，X^2=6．449，P=0．040]。甲减组尿碘中位数水平最低[232．5（69．2-1682．3）μg/L]，甲亢组最高[331．9（102．4-1862）μg/L，X^2=15．432，P〈0．01]。甲状腺过氧化物酶抗体（TPOAb）及甲状腺球蛋白抗体（TGAb）增高组与正常组的尿碘中位数水平无差异（P〉0．05）。单发结节、多发结节组、正常组间尿碘中位数水平比较无差异（P〉0．05）。结论本研究调查的宁夏部分地区人群均达到碘超足量。

Objective To investigate the correlation between iodine nutritional status and thyroid diseases in some areas of Ningxia. Methods The physical examination, questionnaire survey, and measurement of urine iodine, thyroid function, thyroid associated antibodies were performed, with thyroid ultrasonography in Jingyuan County, Xingqing District and Guyuan City, Ningxia Yinchuan City, totally including 2 827 adults. Results The median urinary iodine of all subjects was 258.7 （76.6-506.4） μg/L. The average level of urinary iodine in rural areas I203.3 （64.6-1 154） μg/Ll was lower than that in cities 1 340. 7 （114. 8-1726. 1 ） μg/L, Z-- 19. 514, P 〈 0.011. The average urinary iodine level was lower in people over 65 years old 1234.2 （ 58.9-2 285.4 ） p,g/L, X2 = 6. 449, P = 0. 0401- Subjects in hypothyroidism group 1 232.5 （ 69.2-1 682.3 ） μg/L J had the lowest average urinary iodine level, while hyperthyroidism group E 331.9 （ 102.4-1 862 ） μg/L] turned to be the highest group （X2 = 15. 432, P〈0.01 ）. Compared with the normal group, TPOAb and TGAb increased group had similar median levels of urinary iodine （P〉0.05）. If compared with single nodule, multiple nodules group and the normal group＇s median levels of urinary iodine also had no significant difference （ P 〉 0.05 ）. Conclusion Iodine excess was found in the studied population in these areas of Ningxia.