摘要
Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On’ and ‘On to Off’ periods using negatively charged particle-dominant indoor air conditions（NCPDIAC）.Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON’ periods（ON trials） for a total of 16 times,and ‘ON to 3 months OFF’（OFF trials） periods for a total of 13 times.Results With the exception of one case,serum amyloid A（SAA） levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein（CRP）,this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events.
Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On’ and ‘On to Off’ periods using negatively charged particle-dominant indoor air conditions（NCPDIAC）.Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON’ periods（ON trials） for a total of 16 times,and ‘ON to 3 months OFF’（OFF trials） periods for a total of 13 times.Results With the exception of one case,serum amyloid A（SAA） levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein（CRP）,this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events.
作者
Suni Lee
Shoko Yamamoto
Yasumitsu Nishimura
Hidenori Matsuzaki
Kei Yoshitome
Tamayo Hatayama
Miho Ikeda
YU Min
Nagisa Sada
Naoko Kumagai-Takei
Takemi Otsuki
Suni Lee;Shoko Yamamoto;Yasumitsu Nishimura;Hidenori Matsuzaki;Kei Yoshitome;Tamayo Hatayama;Miho Ikeda;YU Min;Nagisa Sada;Naoko Kumagai-Takei;Takemi Otsuki(Department of Hygiene, Kawasaki Medical School, 577 Mastushima, Kurashiki 701-0192, Japan;Department of Occupational and Environmental Health Science, School of Public Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China;Department of Occupational Diseases, Zhejiang Academy of Medical Sciences＇, Hangzhou 310013, Zhejiang, China;Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushimanaka, Kita-Ku, Okayama 700-8530, Japan)
基金
supported by a Kawasaki Medical School Research Grant(28B051)
