摘要
目的探讨促性腺激素释放激素激动剂(GnRH-a)对腹腔镜卵巢囊肿剔除术患者血清激素水平及基质血流的影响。方法卵巢囊肿患者116例随机均分为观察组和对照组。两组均实施腹腔镜下卵巢囊肿剔除术。观察组术后在月经来潮后第1天给予戈舍瑞林3.6mg皮下注射,每4周1次,共注射4次;对照组术后不用GnRH-a。随访6个月,比较两组血清激素水平和基质血流情况。结果随访6个月,观察组血清卵泡刺激素、促黄体生成素、雌二醇含量均低于对照组(P<0.05或P<0.01);舒张末期最低血流速度、收缩期峰速高于对照组(P<0.01);月经正常(84.48%vs.65.52%)、恢复排卵比例(81.03%vs.58.62%)高于对照组,而复发率低于对照组(5.17%vs.17.24%)(P<0.05)。结论 GnRH-a有助于调节腹腔镜卵巢囊肿剔除术患者血清激素水平,改善基质血流,提高治疗效果。
Objective To investigate the effects of gonadotropin-releasing hormone agonist(GnRH-a)on serum hormone level and stromal blood flow in the patients underwent laparoscopic ovarian cystectomy.Methods One hundred and sixty-one patients with ovarian cysts were equally randomized into two groups.The patients in group A received laparoscopic ovarian cystectomy and given subcutaneous injection of goserelin 3.6 mg after first postoperative menses,which was repeated every other 4 weeks for 3 times.The patients in group C received laparoscopic ovarian cystectomy without injection of goserelin.The patients were followed-up for 6 months and serum hormone levels and stromal blood flow were compared between two groups.Results Serum levels of follicle stimulating hormone,luteinizing hormone and estradiol were lower in group A than those in group C(P〈0.05 or P〈0.01).The end-diastolic minimum velocity and systolic peak velocity were higher in group A than those in group C(P〈0.01).The percentages of the patients with the recovery of normal menstruation and ovulation were higher in group A than those in group C(84.48% vs.65.52% and81.03% vs.58.62%)(P〈0.05).The recurrence rate was lower in group A than that in group C(5.17% vs.17.24%)(P〈0.05).Conclusion GnRH-a is helpful in regulating serum hormone levels,improving the stromal blood flow and enhancing the therapeutic effect in the patients underwent laparoscopic ovarian cystectomy.
作者
张芸
许红霞
ZHANG Yun;XU Hongxia(Department of Obstetrics and Gynecology, Wenrong Hospital ,Jinhua 238300, CHIN)
出处
《江苏医药》
CAS
2018年第5期524-526,共3页
Jiangsu Medical Journal
基金
浙江省中医药大学科技计划项目(2009CB019)