不同分子影像学技术在预测腹主动脉瘤进展中的应用价值

Application of different molecular imaging techniques in predicting the progress of abdominal aortic aneurysm

腹主动脉瘤(abdominal aortic aneurysm,AAA)是临床上较常见的一种致死性主动脉疾病。目前临床常用的影像学诊断方法主要有超声、计算机断层扫描和磁共振成像(MRI)等,但这些手段仅能观察到主动脉的形态学改变,对于动脉瘤的风险评估(如动脉瘤破裂)具有一定的局限性。随着分子影像学成像技术的不断发展以及对AAA发病机制研究的不断深入,正电子发射断层扫描(PET)技术,分子MRI技术和单光子发射计算机断层扫描(SPECT)技术可以从细胞和分子水平观察AAA的病理学改变从而评估其破裂风险。本文就PET、分子MRI、SPECT在AAA风险评估中的最新应用进展进行详细论述。

Abdominal aortic aneurysm （AAA） is a common lethal aortic disease in clinical practice. At present, the imaging diagnostic methods used for AAA mainly include Doppler ultrasound, computed tomography and magnetic resonance imaging （MRI）, but these methods can only observe the morphological changes of the aorta. These techniques used for the risk assessment of aneurysms, such as aneurysm rupture have some certain limitations. With the continuous development of molecular imaging technology and the further understanding of the pathogenesis of AAA, positron emission tomography （PET）, molecular MRI and single photon emission computed tomography （SPECT） techniques can be used to observe the pathological changes of the AAA and assess the risk of rupture from cell and molecular level. In this paper, the latest application of PET, molecular MRI, SPECT in the risk assessment was discussed.