达肺饮汤剂联合塞托溴铵治疗COPD临床疗效及血浆合肽素、hs-CRP影响

Effect of Dafei Yin Combined with Tiotropium Bromide on the Treatment of COPD and Its Effect on the Plasma Copeptin and hs-CRP

目的：研究达肺饮汤剂联合塞托溴铵治疗慢性阻塞性肺疾病（COPD）的临床疗效及对血浆合肽素、hs-CRP的影响。方法：将2015年3月—2016年2月就诊的128例COPD患者按照治疗方法不同分成观察组和对照组两组,对照组应用噻托溴铵进行治疗,观察组在对照组基础上联合达肺饮汤剂进行治疗,两组患者在药物治疗外给予常规基础治疗,观察并且记录两组患者的临床疗效,炎症因子血浆和肽素、超敏C反应蛋白及T细胞亚群CD3^＋、CD4^＋、CD8^＋、CD4^＋/CD8^＋和免疫球蛋白IgG、IgA、IgM变化情况。结果：观察组总有效率为96.9%,对照组的总有效率为81.3%,观察组显著高于对照组,两组差异具有统计学意义（P〈0.05）;观察组患者治疗前超敏C反应蛋白的含量为（12.24±2.21）,对照组的hs-CRP含量为（12.21±2.34）,两组对比差异无统计学意义（P〉0.05）,治疗后,hs-CRP含量下降趋于正常值,与对照组相比,差异显著具有统计学意义（P〈0.05）;炎症因子血浆和肽素治疗前实验组与对照组相比,无显著差异（P〉0.05）,治疗后两组患者血清血浆和肽素水平均呈下降趋势,观察组下降明显与对照组比较显著差异（P〈0.05）;治疗后两组患者血清T淋巴细胞亚群和免疫球蛋白的水平比较差异显著,具有统计学意义（P〈0.05）。结论：达肺饮汤剂联合噻托溴铵治疗慢性阻塞性肺疾病,可以显著降低血清hs-CRP、血浆和肽素水平,提高治疗效果,改善患者的免疫功能。

Objective ：The effect of Dafei Yin combined with tiotropium bromide on the treatment of COPD and its effect on the plasma copeptin and hs-CRP. Methods ：The 128 patients with COPD from March 2015 to February 2016 were divided into two groups according to the different treatment methods,the control group was treated with tiotropium bromide,and the observation group was treated with Dafei Yin on the basis of the control group,the two groups of patients were given routine basic treatment,to observe and record the clinical efficacy of two groups of patients,inflammatory factors and plasma copeptin,hypersensitivity C reactive protein and T cell subsets CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋ and immunoglobulin IgG,IgA and Ig M changes. Results ：The total effective rate of the observation group was 96.9%,the total effective rate of the control group was 81.3%,and the observation group was significantly higher than the control group. The difference between the two groups was statistically significant（P〈0.05）,before treatment,the content of high sensitivity C reactive protein in the observation group was（12.24±2.21）and the hs-CRP content in the control group was（12.21±2.34）. There was no significant difference between the two groups（P〈0.05）. After treatment,the decrease of hs-CRP content tended to a normal value. Compared with the control group,the difference was statistically significant（P〈0.05）. There was no significant difference in plasma copeptin levels between the observation group and the control group before treatment（P〈0.05）. After treatment,the plasma copeptin levels of the two groups showed a decreasing trend,and the observation group decreased significantly compared with the control group（P〈0.05）. After treatment,the levels of serum T lymphocyte subsets and immunoglobulin in the two groups were significantly different,with statistical significance（P〈0.05）. Conclusion ：The effect of Dafei Yin combined with tiotropium bromide on the treatment of chronic obstructive pulmonary disease can significantly reduce the level of serum hs-CRP and plasma copeptin,improve the therapeutic effect and improve the immune function of patients.