抗癌2号方对气血两虚型结直肠癌患者免疫功能和生活质量的影响

Effect of Anti-cancer No.2 Recipe on immune function and quality of life in colorectal cancer patients with Qi-blood deficiency

目的观察抗癌2号方对气血两虚型结直肠癌患者免疫功能和生活质量的影响。方法采用前瞻性研究方法,收集门诊符合标准且完成6个月抗癌2号方中药治疗的60例病例进行自身前后对照研究,观察抗癌2号方对结直肠癌患者免疫功能、临床主要症状评分、Karnofsky体力状况评分的影响。患者开始口服抗癌2号方前及服药6个月后各检测1次免疫指标(外周血T淋巴细胞亚群、CD19以及CD3-CD16/56+),观察服药前后免疫功能的变化,采用Karnofsky体力状况评分观察患者体力状况,同时观察临床主要症状的评分变化。结果服药后,CD3(65.21±9.90)%、CD8(26.19±8.60)%,较服中药前的(66.35±10.23)%和(27.45±9.46)%显著下降,差异无统计学意义(P<0.05);CD4较中药治疗前也所下降,但差异无统计学意义(P>0.05);CD4/CD8、NK细胞、CD19较中药治疗前也有所上升,但差异无统计学意义(P>0.05);临床主要症状评分显著低于服药前。Karnofsky体力状况评分(71.33±8.33)显著高于服药前(68.17±7.48),差异无统计学意义(P<0.01)。结论中药抗癌2号方对结直癌患者的免疫功能有一定的改善作用,主要表现为对T淋巴细胞和B淋巴的调节作用,可以使CD8显著下降,从而使CD4/CD8比值上升,并可使低于正常人群CD19上升到正常范围,并有降低NK细胞的趋势;能显著改善结直肠癌患者临床症状,改善体力状况、提高生活质量。

[Objective]To observe the effect of Anti-cancer No.2 Recipe on immune function and quality of life in colorectal cancer patients with Qi-blood deficiency. [Methods] By the prospective study, a self-control study was performed in 60 patients who met the standard and have completed the treatment of Anti-cancer No.2 Recipe for 6 months, to evaluate the effect of Anticancer No.2 Recipe on immune function, score of clinical major symptom, and Karnofsky physical condition score. The immunological indexes（T lymphocyte subsets, CD19 and CD3-CD16/56 ＋） were measured before oral administration of Anticancer No.2 Recipe and after 6 months of treatment respectively, to observe the immune function before and after treatment. The physical condition of the patients was evaluated by Karnofsky physical condition score, and the scores of the main clinical symptoms were observed. [Results] The levels of CD3（65.21±9.90）% and CD8（26.19±8.60）% after treatment were lower than those before treatment [（66.35±10.23）% and（27.45±9.46）%], and the differences were statistically significant（P〈0.05）, while the CD4 level decreased after treatment, but the difference was not statistically significant（P〉0.05）. The levels of CD4/CD8, NK cells and CD19 increased after treatment, and the differences were statistically significant（P〈0.01）. The scores of the main clinical symptoms after treatment were lower than those before treatment, and the differences were statistically significant（P〈0.01）. The Karnofsky physical condition score（71.33 ±8.33） was higher than that before treatment, and the difference was statistically significant（P〈0.01）. [Conclusion] Anti-cancer No.2 Recipe can improve the immune function of patients with colorectal cancer, mainly for the regulation of T lymphocytes and B lymphocytes, which can decrease CD8 level significantly, so as to increases the ratio of CD4/CD8, raise CD19 level from below normal value to normal range and reduced the NK cells, and it can significantly improve the clinical symptoms of colorectal cancer patients, improve physical condition and enhance quality of life.