幽门螺杆菌根除治疗能否影响胃肠微生态平衡

Would Helicobacter pylori eradication influence dysbiosis of gastrointestinal microbiota

人体胃肠道是微生物种类最多、功能最强大的微生态系统,胃肠道微生态失衡与多种疾病的发生发展密切相关。人幽门螺杆菌(HP)是定植在胃内的一种致病菌,关于HP感染的处理,多个国际指南或国内共识意见均明确给出了主要包含质子泵抑制剂和2种抗生素的根除方案,随着对HP感染认识的加深和治疗方案的普及,HP根除是否会导致胃肠道微生态的失衡并带来失衡相关后果,这一问题日益受到关注。本文将围绕这一问题进行文献综述并提出自己的认识。

Gastrointestinal tract is a microecosystem which is inhabited by the largest number of microbiota with most powerfulfunction in human body. The dysbiosis of gastrointestinal microbiota is closely related to the pathogenesis and progression ofmany diseases. Helicobacter pylori,well-known to us,is a pathogen in stomach. As for the management of H. pylori infection,many international guideline or local consensus have clearly suggested the therapeutic regimens,including H. pylori inhibitionwith proton pump inhibitor and H. pylori eradication with two antibiotics. As the deepening understanding of H. pylori infectionand more common use of its therapeutic regimens,more attention have been paid to whether H. pylori eradication wouldinfluence the dysbiosis of gastrointestinal microbiota and related consequences. This paper gives a review of related literaturesand summarizes my viewpoints.