胰岛素抵抗PCOS患者体内TLHFSE瞍讹及与OV的相关性

目的探讨胰岛素抵抗多囊卵巢综合症（PCOS）患者体内睾酮（T）、黄体生成素（LH）、卵泡刺激素（FSH）变化及与卵巢体积（OV）的相关性。方法根据是否存在胰岛素抵抗，将188例PCOS患者分为胰岛素抵抗组（PCOS-IR组，HOMA-IR≥2．69）和胰岛素非抵抗组（PCOS-NIR组，HOMA-IR〈2．69）。检测两组患者的T、LH、FSH、LH／FSH和OV水平。结果PCOS-IR组的T、OV、LH／FSH水平均显著高于PCOS-NIR组，差异具有统计学意义（P〈0．05）；T、LH／FSH均与OV呈显著正相关（r=0．272、0252，P〈0．05）；以LOV为因变量，T、LH、FSH、LH／FSH、HOMA-IR为自变量的线性回归分析结果显示：T、LH／FSH水平为OV的危险因素。结论胰岛素抵抗PCOS患者体内T上升，OV增大，LH／FSH下降，T、LH／FSH均与OV呈显著正相关。

Objective To investigate the correlation between the changes of testosterone （ T ） , luteinizing hormone （LH） , follicle stimulating hormone （ FSH ） and the ovarian volume （ OV ） in patients with insulin resistance polycystic ovary syndrome （ PCOS ） . Methods According to whether there was insulin resistance, 188 cases of PCOS patients were divided into insuhn resistance group （group PCOS- IR, HOMA-IR ≥2.69） and non insuhn resistance group （group PCOS-NIR, HOMA-IR〈2.69） . The levels of T, LH, FSH, LH/FSH and OV were detected in two groups of patients. Results The levels of T, OV and LH/FSH in group PCOS-IR were significantly higher than those in group PCOS-NIR, and the difference was statistically significant （P〈0.05） ; T and LH/FSH were positively correlated with OV （ r=0.272, 0.252, P〈0.05 ） ; the OV as the dependent variable, T, LH, FSH, LH/FSH and HOMA-IR as independent variables linear regression analysis the results showed that T and LH/FSH levels were the risk factors of OV. Concinsion The increase of T in the patients with insulin resistance PCOS, T increases, OV increases, LH/FSH decreases, T and LH/FSH are positively correlated with OV.