3Thomas MB, Zhu AX. Hepatocellular carcinoma: the need for progress [ J ]. C lini Oncol, 2005, 23 ( 13 ) : 2892-2899.
4Parkin DM, Pisani P, Ferlay J. Global cancer statistics [ J ]. CA Cancer J Clinic,1999, 49(1) : 33-64.
5Barker N,Johan H, Van Es, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5 [ J ]. Nature, 2007, 449(7165) : 1003-1007.
6Jaks V, Barker N, Kasper M, et al. Lgr5 marks cycling,yet longlived, hair follicle stern cells[ J ]. Nature genetics, 2008,40 ( 11 ) : 1291-1299.
7Beeker L, Huang Q, Mashimo H. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett "s esophagus and esophageal adenocarcinoma [ J ]. Dis of the Esophagus, 2010, 23 (2) : 168-174.
8Brabletz S, Schmalhofer O, Brabletz T. Gastrointestinal stem cells in development and cancer[J]. J Pathol, 2009, 217(2): 307-317.
9YaoZ L,Mishra L. Cancer stem cells and hepatocellular carcinoma [ J ]. Cancer biol Ther, 2009, 8 ( 18 ) : 1691-1698.
10Hu C,Zhang R, Wang CR, et al. PPARG, KCNJll,CDKAL1, CDKN2A-CDKN2B, IDE-KIFll-HHEX, IGF2BP2 and SLC3OA8 are associated with type 2 diabetes in a Chinese population [ J ]. PLoS One, 2009, 4(10) : e7643.
