Rosai-Dorfman病1例报告并文献复习

Rosai-Dorfman disease:a case report and literature review

Rosai-Dorfman病1961年由Lennert首先报告,1969年Rosai和Dorf-man对此病进行了总结,并命为窦组织细胞增生症伴巨淋巴结病,后来发现该病还可同时累及淋巴结外的不同部位,甚至可单独发生于淋巴结外而不伴淋巴结肿大,故目前多称为Rosai-Dofmran病（RDD）。该病为罕见疾病,临床表现多样,因此临床上易被误诊。

Rosai-Dorfman disease（RDD）also known as sinus histiocytosis with massive lymphadenopathy（SHML）is a rare benign disorder which usually characterized by massive painless cervical lymphadenopathy and systemic manifestations.Extranodal involvement is rare.We report a 64-year-old man who presented with voice hoarseness,nasal obstruction and pain.He was diagnosed as plasmacytoma,rhinoscleroma on the basis of biopsy results.The patient developed painless cervical lymphadenopathy as the disease progressed,so we performed surgical resection.Based on the histologic features and immunoreactivity for the S-100 protein and CD68,a diagnosis of RDD was made.There is still no consensus regarding appropriate therapy for RDD.We discussed its clinical and histopathologic features,differential diagnoses and treatment options.The unusual presentation of this case serves as a reference when diagnosing and treating RDD.