分析马来酸依那普利叶酸片治疗老年性H型高血压的临床疗效

To Analyze the Clinical Efficacy of Enalapril Maleate and Folic Acid Tablets in the Treatment of Senile Type H Hypertension

目的研讨老年性H型高血压患者使用马来酸依那普利叶酸片治疗对血压及血浆同型半胱氨酸(Hcy)水平的影响。方法选择2017年1月至12月在我院诊疗的30例老年性H型高血压患者作随机非盲实验并分组,Ⅰ组使用马来酸依那普利片口服,10mg/次,每日1次;Ⅱ组接受马来酸依那普利叶酸片治疗,10mg/次,每日1次。观察评估两组治疗1个疗程后的血压、Hcy水平,同时统计新发脑卒中及其他药物副反应的发生情况。结果与Ⅰ组相比,Ⅱ组患者不同施治阶段的SBP、DBP及血浆Hcy水平均显著下降,比较有统计学意义(P<0.05)。Ⅱ组实验期间1例(6.7%)新发脑卒中,与Ⅰ组新发脑卒中的发生率33.3%相比,有统计学意义(P<0.05);但在其他药物副反应的对比上,两组发生率无统计学意义(P>0.05)。结论对老年性H型高血压患者实施马来酸依那普利叶酸片治疗是一种可行疗法,能够有效调控患者的血压及血浆Hcy水平,加强预防新发脑卒中的发生,且药物副反应较少,值得推荐。

Objective To investigate the effect of Enalapril Maleate and Folic Acid Tablets on blood pressure and plasma homocysteine（Hcy） in elderly patients with type H hypertension. Methods 30 cases of senile H hypertension patients in our hospital from January 2017 to December were randomly selected and divided into groups. Group Ⅰ was given Enalapril Maleate Tablets oral, 10 mg/times, 1 times a day; Group Ⅱ received Enalapril Maleate and Folic Acid Tablets treatment, 10 mg/times, 1 time per day. The blood pressure and Hcy level of the two groups after 1 courses of treatment were observed and evaluated. Meanwhile, the incidence of new stroke and other drug side effects was also recorded. Results Compared with group Ⅰ, the levels of SBP, DBP and plasma Hcy in group Ⅱ were significantly decreased at different administration stages（P〈0.05）. One stroke in group Ⅱ（6.7%） during the experiment was statistically significant（P〈0.05） compared with the incidence of new stroke in group Ⅰ（33.3%）. However, in contrast to the side effects of other drugs, The incidence of the two groups was not statistically significant（P〉0.05）. Conclusion The administration of enalapril maleate folic acid tablets is an effective therapy for senile Hypertension patients, which can effectively control the blood pressure and plasma Hcy levels of patients and strengthen the prevention of new stroke. And the drug side reaction is less, it is worth recommending.