期刊文献+

动力系统模型在红霉素用药分析中的应用

The Application of Dynamical System Model in the Analysis of Erythromycin
下载PDF
导出
摘要 儿童用药是医学界以及所有父母迫切关注的,尤其是抗生素类药物更是慎之又慎.根据硬脂酸红霉素药理说明,运用动力系统模型,进而分析出给儿童服用此类抗生素药物既能达到很好药效,又能做到用药安全系数高的方法. Children's drugs is urgent attention in the medical community and all parents,especially about antibiotic medicines. In this paper,the system model according to erythromycin pharmacological stearate is established,and then it is analyzed on how to give children the antibiotic drugs can achieve very good effect,and high safety.
作者 丁慧 Ding Hui(Suihua Colleg)
机构地区 绥化学院
出处 《哈尔滨师范大学自然科学学报》 CAS 2018年第1期73-75,共3页 Natural Science Journal of Harbin Normal University
关键词 动力系统 平衡点 硬脂酸红霉素 Dynamical system Balance point Ergthromycin stenrate
  • 相关文献

参考文献4

二级参考文献60

  • 1NAVARRO V J, SENIOR JR. Drug-related hepatotoxicity[J]. N Engl J Med, 2006, 354(7) :731 -739.
  • 2BJORNSSON ES. Drug-induced liver injury : an overview over the most critical compounds [ J]. Arch Toxicol, 2015,89 ( 3 ) : 327 - 334.
  • 3IKEDA T. Idiosyncratic drug hepatotoxicity: strategy for preven- tion and proposed mechanism[ J]. Curr Med Chem,2015,22(4) : 528 - 537.
  • 4USUI T, MISE M, HASHIZUME T, et al. Evaluation of the poten- tial for drug-induced liver injury based on in vitro covalent bind- ing to human liver proteins [ J ]. Drug Metab Dispos, 2009,37 (12) :2383 -2392.
  • 5GARSIDE H, MARCOE KF, CHESNUT-SPEELMAN J, et al. Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes [ J ]. Toxicol In Vitro,2014,28(2) :171 - 181.
  • 6PORCEDDU M, BURON N, ROUSSEL C, et al. Prediction of liver injury induced by chemicals in human with a muhiparamet- rie assay on isolated mouse liver mitochondria [ J ]. Toxicol Sci, 2012,129(2) :332 - 345.
  • 7VAN STADEN C J, MORGAN RE, RAMACHANDRAN B, et al. Membrane vesicle ABC transporter assays for drug safety assess-ment[ M ]. Curr Protoc Toxicol,2012, Chapter23 : Unit23.5.
  • 8GODOY P, HENGSTLER JG, ILKAVETS I, et al. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedif- ferentiation and transforming growth factor beta-induced apoptosis [ J ]. Hepatology, 2009,49 ( 6 ) : 2031 - 2043.
  • 9BORLAK J, CHOUGULE A, SINGH PK. How useful are clini- cal liver function tests in in vitro human hepatotoxicity assays [ J]. Toxicol In Vitro ,2014,28 ( 5 ) : 784 - 795.
  • 10叶秀珍,朱德厚,沈鼎武.体外连续培养的成人肝细胞的超显微结构[J].实验生物学报,1980,13(4):361-369.

共引文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部