脑蛋白水解物联合阿司匹林对脑梗死二次发作预防效果观察

Observation of prevention effect of cerebrolysin combined with Aspirin on secondary attack of cerebral infarction

目的:观察脑蛋白水解物联合阿司匹林对脑梗死二次发作的预防效果。方法:220例脑梗死患者随机分为两组,实验组110例应用注射用脑蛋白水解物联合阿司匹林,对照组110例仅服用阿司匹林。比较两组患者治疗1年后的疗效及不良事件发生率。结果:两组患者治疗1年后全血黏度高切、全血黏度低切、血浆黏度、纤维蛋白原含量均较治疗前降低,且实验组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗1年后TC、TG水平较治疗前明显降低,且实验组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗1年后NIHSS评分和barthel指数均较治疗前改善,且实验组均优于对照组,差异有统计学意义(P<0.05)。治疗1年后,实验组脑缺血性事件发生率显著低于对照组,两组比较有统计学意义(P<0.05)。结论:脑梗死患者采用脑蛋白水解物联合阿司匹林药物治疗可降低脑缺血事件的发生率,可用于脑梗死患者的二级预防。

Objective： To observe the prevention effect of cerebrolysin combined with Aspirin on secondary attack of cerebral infraction. Methods： 220 cases with cerebral infraction were divided into two groups randomly： the experimental group（ n = 110）,treated with cerebrolysin combined with Aspirin,the control group（ n = 110）,treated with only Aspirin. The efficiency and incidences of adverse events of two groaps after 1 year post-therapy were compared. Results： The whole blood high shear viscosity,low shear viscosity,plasma viscosity and fibrinogen level of two groups in 1 year post-therapy were lower than these in pre-therapy,and these indicators in 1 year post-therapy of the experiment group were lower than these in1 year post-therapy of the control group,with the statistically significant（ P〈0.05）. The levels of TC and TG of two groups in 1 year post-therapy were lower than these in pre-therapy,and these indicators in 1 year post-therapy of the experiment group were lower than these in 1 year post-therapy of the control group,with the statistically significant（ P〈0.05）. The NIHSS score and barthel indicators of two groups in 1 yearpost-therapy got remarkably improved than these in pre-therapy,and these indicators in 1 year post-therapy of the experiment group were superior than these in 1 year post-therapy of the control group,with the statistically significant（ P〈0.05）. The cases of cerebral ischemic events in the experiment group in 1 year post-therapy were evidently lower than that in control group,with the statistically significant（ P〈0. 05）.Conclusion： Cerebrolysin combined with Aspirin can decrease the incidence rate of cerebral ischemic events of patients with cerebral infraction,and can be used for the secondary prevention of cerebral infraction.