NLR预测进展期胃癌化疗疗效的临床价值

Clinical value of chemotherapy efficacy in NLR forecast of advanced stomach cancer

目的:观察外周血粒淋比(NLR)预测进展期胃癌化疗疗效的临床价值。方法:选取118例进展期胃癌患者为研究对象,均给予新辅助化疗治疗,按照血细胞分类计数计算NLR,以NLR中位数3为最佳临界点,将患者分为A组(NLR<3)59例,B组(NLR≥3)59例,比较两组化疗疗效,并分析患者性别、年龄、肿瘤部位、TNM分期、有无淋巴结转移、分化程度对预后的影响。结果:A组有效率64.41%,显著高于B组37.29%(P<0.05),两组TNM分期、有无淋巴结转移比较差异有统计学意义(P<0.05)。结论:TNM分期越晚、有淋巴结转移为影响进展期胃癌的危险因素,NLR可用于预测进展期胃癌化疗疗效及预后。

Objective： To observe the clinical value of chemotherapy efficacy of NLR forecast in advanced stomach cancer. Methods： 118 cases of advanced stomach cancer served as objects of study,given the new auxiliary chemotherapy treatment,calculated NLR according to the blood corpuscle classification counting,taking the NLR median 3 as the best critical point,divided into the patient group A of（ NLR3） 59 cases,group B（ NLR≥3） 59 cases,compared with two group of chemotherapy curative effects,and analyzed the influence of sex,age,tumor spot,TNM stages,lymph node shift,and differentiation degree to prognosis.Results： The effective rate of group A was 64. 41%,higher than 37. 29% of group B with the statistics significance（ P〈0.05）. The difference of TNM stages and lymph node shift of the two group had statistics significance（ P〈0.05）. Conclusion： With TNM stages later,and the lymph node shift are the dangerous factor in advanced stomach cancer. NLR may be available in the forecast the chemotherapy curative effect and the prognosis of advanced stomach cancer.