三阴性乳腺癌雄激素受体靶向治疗的研究进展

Progress on Targeting Androgen Receptor in Triple Negative Breast Cancer

三阴性乳腺癌是一组特殊亚群的乳腺癌,侵袭性较强,不能从传统的内分泌治疗和抗Her-2靶向治疗获益,预后较差。近来研究表明,雄激素受体在三阴性乳腺癌的发生发展中扮演重要角色,雄激素受体有望成为新的治疗靶点。目前,针对三阴性乳腺癌雄激素受体的靶向治疗崭露头角。全文就雄激素受体在三阴性乳腺癌靶向治疗研究进展作一综述。

Triple negative breast cancer（TNBC） is considered as a specific subtype characterized by more aggressive course and poorer overall survival,and can not benefit from traditional endocrine therapy and Her2-targeted therapy. Recent studies demonstrate that androgen receptor（AR） may play an important role in the tumorigenesis of TNBC and could serve as a promising therapeutic target in TNBC. At present,evidence targeting androgen receptor in TNBC is emerging. This review summarizes the current research and future development of therapeutic strategies targeting AR in TNBC.