针灸治疗早发性卵巢功能不全的国际病例登记注册研究:挑战与机遇（英文）

International patient registry on acupuncture therapy for premature ovarian insufficiency:Challenges and opportunities

早发性卵巢功能不全严重影响患者身心健康。针灸治疗有一定效果,但临床证据不足,因此我们采用国际病例登记注册的方法,对真实世界中针灸治疗的有效性与安全性开展研究。我们将面临一系列机遇与挑战。机遇是(1)多学科合作有助于提高针灸治疗早发性卵巢功能不全的疗效;(2)针灸治疗方案有待进一步优化以提高疗效;(3)病例登记注册研究能够弥补随机对照试验的缺点;(4)收集真实世界数据能够挖掘有效人群,为后续研究提供基础。国际针灸病例登记研究也面临技术,伦理以及基金支持的挑战,但已建成的国际针灸病例注册登记研究平台(www.amreg.org:8082/v3)正在积极应对挑战,至今已经收集了300多例早发性卵巢功能不全患者的诊疗数据。

Premature ovarian insufficiency（POI） affects seriously physical and mental health of the patients. Studies show that acupuncture may be promising in treating POI. yet evidence is insufficient. International patient registry, one form of observational study, is designed for evaluating effectiveness and safety of acupuncture in real-world clinical settings. We will face a series of opportunities and challenges. The opportunities are as follows：（1） Interdisciplinary cooperation can improve the effect of acupuncture for POI.（2） The protocol for acupuncture to treat POI has room for improvement.（3） The patient registry study can make up the shortcomings of randomized controlled trials.（4） The patient registry study can collect real-world data and explore responses of different populations to acupuncture and can be the foundation for the successive studies. International patient registry may face technological, ethical and financial challenges, while the established International Patient Registry Platform of Acupuncture-Moxibustion（www.amreg.org：8082/v3） is actively responding to these challenges. Till now there have been more than 300 patients of POI enrolled on this platform.