摘要
MXH10/Mo-lpr/lpr鼠表现为全身性的淋巴结肿大,6周龄时淋巴结直径可达1 cm。与其亲代MRL/lpr鼠相比,MXH10/Mo-lpr/lpr鼠有较轻的肾小球肾炎、血管炎、关节炎、唾液腺炎等症状且生命周期长。基于这些特点,MXH10/Mo-lpr/lpr鼠主要用于肿瘤淋巴结转移、淋巴管给化疗药的研究,并应用于小动物CT和MRI的诊断,为临床提供早期淋巴结转移诊断奠定可靠的临床前动物模型。本文将对MXH10/Mo-lpr/lpr鼠的遗传背景、特征性表型和应用加以概述,并介绍其在肿瘤诊断与治疗方面的应用。
This review introduces the MHX10/Mo-lpr/lpr mice that it shows the systemic lymph node swelling,up to 1 cm in diameter. Compared with lupus mice called MRL/lpr,the MHX10/Mo-lpr/lpr mice have lighter glomerulonephritis,vasculitis, arthritis, salivary gland inflammation and longer life cycle. Based on these characteristics,MHX10/Mo-lpr/lpr mice are chosen to establish lymph node metastasis model; to inject chemotherapy drugs to the central of lymph node to kill residual cancer cells in the lymph vessels and lymph nodes though lymph drug delivery system; to establish diagnostic criteria of lymph node metastasis with small animals CT and MRI, and to provide reliable preclinical experimental animal model for early diagnosis of clinical LN metastasis. This article summaries MXH10/Mo-lpr/lpr mice genetic background,characteristic phenotype and application prospect.
作者
吕誉坤
彭艳
贾立敏
李明卿
郑金华
LU Yukun;PENG Yan;JIA Limin;LI Mingqing;ZHENG Jinhua(Stomatology Hospital, Harbin Medical University, Harbin 150001, China;School of Basic Medical Sciences,Harbin Medical University,Harbin 150081, China)
出处
《实验动物科学》
2018年第2期74-78,共5页
Laboratory Animal Science
