神经母细胞瘤分子治疗研究进展

Research progress in the molecular therapy of neuroblastoma

神经母细胞瘤（NB）是儿童颅内外最常见的恶性肿瘤，也是婴幼儿最常见的恶性肿瘤。对于低危组神经母细胞瘤，手术治疗通常能取得良好的效果，对于高危组神经母细胞瘤，综合各种治疗方案，仍疗效欠佳。肿瘤的分子生物学治疗为肿瘤的治疗开辟了新的思路。本文主要从NB分子治疗着手，介绍目前具有潜在价值的NB分子治疗方案，为NB的分子靶向治疗提供临床依据。

Neuroblastoma is the most common solid extracranial malignancy in infants. For low- risk neuroblastoma, surgery usually yields excellent outcomes. For high-risk neuroblastoma, the curative effect has remained poor despite various treatment schemes. Molecular biological therapy sheds light on new therapeutic ideas. New promising therapies are discussed.