亚临床甲状腺功能减退对冠心病患者Ghrelin/obestatin比值的影响

Effect of subclinical hypothyroidism on Ghrelin/obestatin ratio in patients with coronary heart disease

目的探讨亚临床甲状腺功能减退对冠心病患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值的影响及与冠脉病变的相关性。方法选取冠心病患者94例作为研究对象,根据是否合并亚临床甲状腺功能减退分为观察组(45例)和对照组(49例)。采用ELISA法测定血清Ghrelin、obestatin水平。根据冠脉造影结果采用Gensini积分评估冠脉病变程度。结果观察组血清TSH、Gensini积分较对照组明显升高;而Ghrelin/obestatin比值较对照组明显降低,差异均有统计学意义(P<0.05)。Spearman相关性检验显示,观察组患者Ghrelin/obestatin比值与TSH水平、Gensini积分呈负相关(r值分别为-0.573、-0.673,P<0.05)。结论亚临床甲减可加重冠心病患者病变的严重程度,导致Ghrelin/obestatin比值明显降低。

Objective To investigate the effect of subclinical hypothyroidism on Ghrelin/obestatin ratio in patients with coronary heart disease and its correlation with coronary artery disease. Methods Ninety-four cases of coronary heart disease were selected as the study subjects,and divided into the observation group（ n = 45） and the control group（ n = 49） according to whether subclinical hypothyroidism was combined. The levels of serum Ghrelin and obestatin were measured by enzyme-linked immuno sorbent assay（ ELISA）. Gensini score was used to evaluate the severity of coronary artery disease according to coronary angiography. Results The serum TSH and Gensini scores in the observation group were significantly higher than those in the control group,while the Ghrelin/obestatin ratio was significantly lower than that of the control group,with the differences statistically significant（ P〈0. 05）. Spearman correlation test showed that the Ghrelin/obestatin ratio in the observation group was negatively correlated with TSH level and Gensini score（ r =-0. 573,r =-0. 673,P〈0. 05）. Conclusion Subclinical hypothyroidism can aggravate the severity of coronary heart disease,resulting in significant reduce of Ghrelin/obestatin ratio.