基于LDA主题模型和关联规则的冠心病方剂组方规律分析

Analysis on Composing Prescriptions Rules of Prescriptions of Coronary Disease Based on LDA Topic Model and Association Rules

目的:运用数据挖掘技术,分析中医治疗冠心病方剂的组方规律。方法:收集整理中医文献及CNKI中有关冠心病的方剂,建立方剂数据库。运用关联规则及LDA主题模型分别从药物关联性和方剂潜语义分析两个角度对冠心病方剂进行挖掘,分析冠心病方剂的组方规律。结果:收集冠心病方剂356首,涉及中药318味,药物频次统计结果表明冠心病方剂中的药物以补气药、活血化瘀药和理气药为主。LDA主题模型共得到3个方剂主题,关联规则挖掘得到12个提升度较大的药对组合和药物关联规则。结论:中医治疗冠心病以益气、活血化瘀为主,兼顾理气祛痰,注重标本兼治。运用数据挖掘方法分析冠心病方剂组成,可以发现其组方规律,为临床冠心病治疗提供参考依据。

Objective：To analyze the composing prescriptions rules of prescriptions of Chinese medicine for coronary disease by data mining technology.Methods：Collected and arranged prescriptions of coronary disease in CNKI and literature of Chinese medicine,and established database of prescriptions.Association rules and Latent Dirichlet Allocation LDA topic model were used to respectively explore the prescriptions of coronary disease from the aspects of medicine association and latent semantic analysis of prescriptions,and to analyze the composing prescriptions rules of prescriptions of coronary disease.Results：356 cases of prescriptions of coronary disease were collected,including 318 kinds of Chinese medicine.The statistical results of medicine frequency showed that the medicines in the prescriptions mainly are qi-invigorating medicine,blood-activating and stasis-resolving medicine and qi-regulating medicine.Three topics of prescriptions were concluded by LDA topic model and 12 combinations of couplet medicines with higher upgrade degree and association rules of medicine were explored by association rules.Conclusion：Chinese medicine therapy for coronary disease focuses on tonifying qi and activating blood and resolving stasis,takes regulating qi and dispelling phlegm into consideration,and emphasizes that the treatment of the disease should attach importance to both the root cause and the symptoms.Through the analysis of the composition of prescriptions of coronary by the data method,the composing prescriptions rules can be found,which provides a reference for clinical treatment of coronary disease.