雷公藤联合白芍总苷治疗类风湿关节炎临床观察

Clinical Observation of Tripterygium Wilfordii Polyglycosidium Combined with Total Glucosides of Paeony for Rheumatoid Arthritis

目的:探讨雷公藤(TWP)联合白芍总苷(TGP)治疗对类风湿关节炎(RA)免疫功能的影响,并综合评估临床疗效。方法:纳入本院收治的RA患者78例,根据入院顺序分为2组各39例。对照组给予单独TGP治疗,观察组给予TWP+TGP方案治疗,均持续治疗3月。观察2组治疗前后相关免疫指标表达变化和症状改善情况,并综合评估治疗效果和不良反应情况。结果:本研究无中途退出或脱落病例。2组治疗后CD3^+、CD8^+有明显升高,CD4^+、CD4^+/CD8^+显著降低,差异均有统计学意义(P<0.05);2组治疗后比较,差异有统计学意义(P<0.05)。2组治疗后晨僵时间、关节肿胀和压痛指数均有显著降低(P<0.05);治疗后组间比较,观察组上述指标降低更为显著(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。2组治疗期间用药较为平稳,均未出现严重不良反应。结论:TWP联合TGP可有效改善R A患者免疫功能和症状体征,治疗效果和安全性均较好。

Objective：To discuss the effect of tripterygium wilfordii polyglycosidium（TWP）combined with total glucosides of paeony（TGP）on rheumatoid arthritis（RA）,and comprehensively evaluated its clinical effect.Methods：Selected 78 cases of RA patients admitted and treated in our hospital,and divided them into two groups according to the order of hospitalization,39 cases in each group.The control group was given the simple TGP for treatment,while the observation group was given the protocol of TWP combined with TGP for treatment.The treatment for both groups lasted for 3 months continuously.Observed the changes of relevant immune indexes and the improvement of symptoms in both groups before and after treatment,and comprehensively evaluated the clinical effect and adverse reactions.Results：No cases withdrew halfway or dropped out in this research.After treatment,CD3-＋ and CD8-＋ in both groups were significantly increased,CD4-＋ and CD4-＋ /CD8-＋ were significantly decreased,differences being significant（P〈0.05）;when comparing in-between the two groups after treatment,there was significant difference being found（P〈0.05）.After treatment,the indexes of morning stiffness,joint swelling and tenderness in both groups were all significantly decreased（P〈0.05）;when comparing in-between the two groups after treatment,each index above in the observation group was reduced more evidently（P〈0.05）.The total effective rate in the observation group was higher than that in the control group,difference being significant（P〈0.05）.During the treatment,the medication administration in both groups was quite stable,and no severe adverse reactions occurred.Conclusion：TWP combined with TGP can effectively improve the immune function,symptoms and signs of RA patients with good clinical effect and safety.