保妇康栓联合左氧氟沙星治疗衣原体感染性慢性宫颈炎疗效观察

Observation of Baofukang Suppository Combined with Levofloxacin for Chlamydia Infectious Chroni Cervicitis

目的:观察保妇康栓联合左氧氟沙星片治疗衣原体感染性慢性宫颈炎的临床疗效。方法:以192例衣原体感染性慢性宫颈炎患者为研究对象,按照随机数字表法分为对照组和研究组各9 6例,对照组给予左氟氧沙星片治疗,研究组给予保妇康栓联合左氧氟沙星片行中西医结合治疗,记录治疗期间2组患者的药物不良反应情况,于治疗前后分别检测2组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-2(I L-2)、白细胞介素-6(I L-6)和超敏C-反应蛋白(hs-CRP)水平,疗程结束后评价2组的宫颈炎疗效,随访患者治疗结束6月后的宫颈炎复发情况。结果:疗程结束后,研究组总有效率92.71%,高于对照组的80.21%,差异有统计学意义(P<0.05)。研究组不良反应发生率为6.25%,对照组不良反应发生率为5.21%,2组比较,差异无统计学意义(P>0.05)。除此以外,2组患者均无严重药物不良反应发生。2组TNF-α、hs-CRP、IL-1、IL-2和I L-6水平均较治疗前降低,研究组各炎症因子水平均低于对照组,差异均有统计学意义(P<0.05,P<0.01)。研究组宫颈炎复发率10.42%,低于对照组的21.88%,差异有统计学意义(P<0.05)。结论:较左氧氟沙星片单方治疗,保妇康栓联合左氧氟沙星的中西医结合治疗方案可更有效地降低慢性宫颈炎患者的炎症反应程度,提高宫颈炎治疗的总体疗效,预防病情复发,且无严重药物不良反应,值得在妇科临床推广使用。

Objective：To observe the clinical effect of baofukang suppository combined with levofloxacin tablets for chlamydia infectious chronic cervicitis.Methods：Selected 192 cases of patients with chlamydia infectious chronic cervicitis as study objects and divided them into the control group and the study group randomly according to random number table method,96 cases in each group.The control group was given simple prescription of western treatment of levofloxacin tablets,while the study group was given integrated Chinese and western medicine treatment of baofukang suppository combined with levofloxacin tablets.Recorded adverse reactions of patients in the two groups during treatment and detected levels of serum tumor necrosis factor-α（TNF-α）,interleukins-1（IL-1）,interleukins-2（IL-2） and interleukins-6（IL-6） and high sensitive C-reactive protein（hs-CRP）of patients in the two groups before and after treatment.After treatment,evaluated the level of the effect of cervicitis in the two groups.The recurrence of cervicitis of patients was followed up on the sixth month after treatment.Results：After treatment,the total effective rate was 92.71% in the study group,higher than that in the control group which was 80.21%,the difference being significant（P〈0.05）.The adverse reaction rate was 6.25% in the study group and was 5.21% in the control group,there was no significance in the difference（P〈0.05）.Besides,no serious adverse reaction was found in the two groups.Levels of TNF-α,hs-CRP,IL-1,IL-2 and IL-6 in the two groups were decreased when compared with those before treatment,and levels of inflammatory factors in the study group were all lower than those in the control group,differences being significant（P〈0.05,P〈0.01）.The recurrence rate of cervicitis was 10.42% in the study group,lower than that in the control group which was 21.88%,the difference being significant（P〈0.05）.Conclusion：Compared with the treatment of simple prescription of trachomatis infectious,integrated Chinese and western medicine treatment of baofukang suppository combined with levofloxacin tablets can more effectively decrease inflammatory reaction degree of patients with chronic cervicitis,improve general efficacy of treatment of cervicitis and prevent the recurrence of disease with no serious adverse reaction,which is worthy of clinical promotion and application in gynecology.