加减黄芪桂枝五物汤对口腔黏膜白斑免疫应答的影响

Modified Huangqi Guizhi Wuwu Tang Has Effect on Immune Response of Oral Leukoplakia

目的:观察加减黄芪桂枝五物汤治疗口腔黏膜白斑的临床疗效及其对免疫应答的影响。方法:选取在本院口腔科就诊的口腔黏膜白斑患者78例,将患者随机分为2组各39例。对照组口服转移因子胶囊加局部使用维生素AD制剂治疗;治疗组口服加减黄芪桂枝五物汤加局部使用维生素AD制剂治疗。疗程均为30天,疗程结束后分别观察2组患者临床疗效、治疗前后白斑变化情况和免疫球蛋白的变化情况。结果:总有效率治疗组94.87%,高于对照组74.36%,差异有统计学意义(P<0.05)。治疗后,2组白斑最大直径和黏膜白斑数目均有改善,免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)分别与治疗前比较,差异均有统计学意义(P<0.05);且治疗组治疗后白斑最大直径和黏膜白斑数目、IgA、IgM、IgG变化分别与对照组比较,差异均有统计学意义(P<0.05)。2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加减黄芪桂枝五物汤对口腔黏膜白斑有明显疗效,可改善临床症状,并有助于提高患者的免疫应答。

Objective：To observe the clinical effect of modified Huangqi Guizhi Wuwu tang for oral leukoplakia and its effect on immune response.Methods：Selected 78 cases of patients with oral leukoplakia admitted in our department of stomatology,and divided them randomly into two groups,39 cases in each group.The control group received transfer factor capsules orally and vitamin AD preparations locally for treatment,while the treatment group received modified Huangqi Guizhi Wuwu tang orally and vitamin AD preparations locally.The treatment of the two groups lasted for 30 days.After treatment,respectively observed the clinical effect and changes of leukoplakia and immunoglobulin before and after treatment in the two groups.Results：The total effective rate was 94.87% in the treatment group,higher than that of 74.36% in the control group,the difference being significant（P〈0.05）.After treatment,the maximum diameter and the number of leukoplakia in the two groups were improved,and the comparisons of immunoglobulin A（IgA）,immunoglobulin M（IgM）and immunoglobulin G（IgG）before and after treatment showed significance in differences（P〈0.05）.The comparisons of the maximum diameter and the number of leukoplakia and changes of IgA,IgM and IgG after treatment between the two groups showed significance in differences（P〈0.05）.No significant difference was found in the comparison of the incidence of adverse reactions between the two groups（P〉0.05）.Conclusion：The therapy of modified Guizhi Wuwu tang has significant curative effect in treating oral leukoplakia,which can effectively improve clinical symptoms and improve immune response of patients.