尿毒清颗粒对早中期慢性肾衰竭微炎症状态的作用

Effect of Niaoduqing Granule on Microinflammatory State in Patients with Chronic Renal Failure in Early and Middle Stage

目的：探讨尿毒清颗粒对早中期慢性肾衰竭患者微炎症状态的作用。方法：选择2015年11月—2016年9月之间在医院肾内科病房住院的慢性肾功能衰竭病人80例,按照随机数字的方法,将80例患者分为对照组和观察组,每组各40例,分别给予常规治疗和加用尿毒清颗粒的方法,对比两种方法的结果。结果：在进行治疗前,两组的血尿素氮,血清肌酐,血尿酸,血红蛋白,血清白蛋白,钙离子,磷离子,白细胞介素-1β,白细胞介素-6和C反应蛋白的数值未出现统计学差异（P〉0.05）,经过治疗后,两组的数据与治疗前相比,均出现统计学差异（P〈0.05）,而且在血尿素氮,血清肌酐,血尿酸,磷离子,白细胞介素-1β,白细胞介素-6和C反应蛋白几个项目上,均为治疗后的数值低于治疗前,而在血红蛋白,血清白蛋白和钙离子几个项目上,均为治疗后的数值高于治疗前,在治疗后,对照组与观察组在以上项目的比较中也都出现了统计学差异（P〈0.05）,而且在血尿素氮,血清肌酐,血尿酸,磷离子,白细胞介素-1β,白细胞介素-6和C反应蛋白几个项目上,均为观察组低于对照组,而在血红蛋白,血清白蛋白和钙离子几个项目上,均为观察组高于对照组。结论：尿毒清颗粒在早中期慢性肾衰竭患者的使用,可以清除患者体内的毒素,降低炎症反应,改善肾功能,调节钙磷比,促进蛋白质合成,改善患者的微炎症状态,值得在更广大的临床范围内进行推广。

Objective：To investigate the effect of Niaoduqing Granule on microinflammatory state in patients with chro- nic renal failure. Methods ： Eighty patients with chronic renal failure who were hospitalized in our hospital from November 2015 to September 2016 were randomly divided into control group and observation group according to the random number method. Each group＇ s 40 patients were given conventional treatment and the observation group additionly used Niaoduqing Granule. We compared the results of the two methods. Result：The levels of serum urea nitrogen, serum creatinine, serum uric acid, hemoglobin, serum albumin, calcium ion, phosphorus ion, interleukin - 1β, interleukin - 6 and C - re- active protein in the two groups were significant（P 〈 0. 05）. After treatment, the data of the two groups was statistically different（P 〈 0. 05 ） and the blood urea nitrogen, serum creatinine, blood uric acid, phosphorus ion, Interleukin - 113, interleukin - 6 and C - reactive protein of the observation group were lower than those before treatment, and hemoglobin, serum albumin and calcium were significant （P 〈 0.05） and blood urea nitrogen, serum creatinine, serum uric acid and phosphorus ion were also significant （P 〈 0. 05 ）, and the difference between the control group and the observation group in the above items was also statistically significant （ P 〈 0. 05 ）. Interleukin - 113, interleukin - 6 and C - reactive protein of the observation group were lower than those of the control group. Conclusion ： In the treatment of chronic renal failure patients at early and middle stage, Niaoduqing Granules can remove the toxins, reduce the inflammatory response, im- prove renal function, regulate calcium and phosphorus ratio, state, worthy of larger promotion. promote protein synthesis and improve microinflammatory