A型肉毒毒素治疗帕金森病合并贲门失弛缓症(附1例报告及文献复习)

Botulinum Toxin Type A in the Treatment of Parkinson's Disease Combined with Achalasia of the Cardia:A Case Report and Literature Review

目的报道1例A型肉毒毒素治疗帕金森病合并贲门失弛缓症病例的临床资料,探讨A型肉毒毒素治疗贲门失弛缓症的疗效。方法对1例帕金森病合并贲门失弛缓症患者,在全身麻醉、胃镜引导下于贲门齿状线上方3、6、9、12钟点方向分别注射A型肉毒毒素各25 U,共计100 U。结合文献复习,分析患者治疗前后的临床表现特征。结果 A型肉毒毒素治疗54 d后,患者吞咽困难/伴有食物反流、胸骨后疼痛等症状较前明显好转。结论并发贲门失弛缓症的老年帕金森病患者,A型肉毒毒素治疗是一种较好的抉择。

Aim A case of botulinum toxin type A in the treatment of Parkinson＇s disease combined with achalasia was reported to discuss the clinical efficacy of botulinum toxin type A in the treatment of achalasia.Methods In a case of Parkinson＇s disease with achalasia in patient under general anesthesia and gastroscopy,in cardiac cardiomyopathy line 3,6,9,12 hour spots were injected with botulinum toxin each 25 U,a total of 100 U.Results Botulinum toxin A treatment for 54 days,the patient with dysphagia,accompanied by regurgitation of food,retrosternal pain and other symptoms was significantly improved.Conclusion The use of botulinum toxin A is a choice for the elderly patients with achalasia.