视神经脊髓炎谱系疾病免疫靶向药物治疗研究进展

Progress of Specifc Targeting Immunotherapy in Neuromyelitis Optica Spectrum Disorder

视神经脊髓炎谱系疾病是一种抗体介导的获得性自身免疫性疾病。近年,多种免疫靶向药物被批准用于治疗视神经脊髓炎谱系疾病。因为疗效确切,靶向性特异性免疫治疗极大的改变了视神经脊髓炎谱系疾病患者的预后。本文将从靶点、疗效、不良反应等方面综述靶向性特异性免疫治疗进展。

Neuromyelitis optica spectrum disorder（NMOSD） is an antibody mediated,acquired autoimmune disorder.Some targeted agents have been approved to treat NMOSD in recent years.Due to specificity and uniformity,symptoms significantly were improved in some NMOSD patients after the targeting immunotherapy.The targets,clinical results and adverse events of specifc targeting immunotherapy in neuromyelitis optica spectrum disorder were reviewed.