神经电生理检查在多灶性运动神经病和慢性炎性脱髓鞘性多发性神经病鉴别诊断中的价值

Utility of electrophysiology in the differential diagnosis of multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy

目的：对比研究多灶性运动神经病（MMN）和慢性炎性脱髓鞘性多发性神经病（CIDP）患者的神经电生理检测结果，探讨这些检查在两者鉴别诊断中的价值。方法：20例MMN和22例CIDP患者，均接受神经电生理检查，比较分析两组间神经电生理改变的特点。结果：MMN与CIDP两组患者运动远端潜伏期（DML）、运动传导速度（MCV）、复合肌肉动作电位（CMAP）波幅、传导阻滞、感觉传导速度（SCV）、感觉神经动作电位（sNAP）波幅对比差异均有统计学意义（P〈0．05）。两组患者肌电图检查中失神经电位、运动单位动作电位（MUAP）形态异常，差异均有统计学意义（P〈0．05）。结论：MMN患者在神经传导及肌电图表现方面与CIDP患者明显不同，神经电生理检查有助于这两种疾病的鉴别。

Objective：To assess the utility of electrophysiology examination in differential diagnosis of patients with multifoca[ motor neuropathy （MMN） and chronic inflammatory demyelinating potyneu-ropathy （CIDP） through contrastive study of electrophysiological features. Methods： Electrophysiology examination was performed in patients of 2 groups, including 20 patients with MMN, and 22 patients with CIDP. The electrophysiologicat features between different groups were compared. Results： There were significant differences in indexes of distal motor latency （DML） , motor nerve conduction velocity （MCV）, compound muscle action potential （CMAP）, sensory conductive velocity （SCV） and Sensory nerve action potential （SNAP） according to the examination of nerve conduction and needle electromyo- graphy between two groups （P〈0.05）. Conclusion： Electrophysiological features in nerve conduction and needle etectromyography shows significant difference,which can help to differentiate MMN from CIDP.