甲巯咪唑联合左旋甲状腺素治疗老年Graves病的临床效果评价

Evaluation on clinical effect of methimazole combined with levothyroxine in the treatment of elderly Graves's disease

目的观察甲巯咪唑联合左旋甲状腺素治疗老年Graves病的临床效果。方法 100例Graves病患者,根据随机抽签的方式分为观察组和对照组,各50例。对照组予以甲巯咪唑治疗,观察组予以甲巯咪唑+左旋甲状腺素治疗。比较两组患者治疗前后高敏促甲状腺激素(sTSH)、游离三碘甲状腺原氨酸(FT_3)及血清游离甲状腺素(FT_4)水平。结果治疗前观察组sTSH、FT_3及FT_4水平与对照组比较差异无统计学意义(P>0.05);治疗后观察组sTSH、FT_3及FT_4水平分别为(1.98±1.13)m IU/L、(2.56±1.79)pmol/L、(12.85±3.08)pmol/L,与对照组的(3.12±1.55)m IU/L、(9.33±5.28)pmol/L、(19.77±5.63)pmol/L比较,差异有统计学意义(P<0.05)。结论甲巯咪唑联合左旋甲状腺素治疗老年Graves病的临床效果极佳,值得采纳。

Objective To observe the clinical effect of methimazole combined with levothyroxine in the treatment of elderly Graves＇ s disease. Methods A total of 100 patients with Graves＇ s disease were divided by random lottery method into observation group and control group, with 50 cases in each group. The control group was treated with methimazole, and the observation group was treated with methimazole ＋ levothyroxine. Comparison were made on high sensitivity thyroid stimulating hormone（sTSH）, free three iodine thyroxine（FT3） and serum free thyroxine（FT4） before and after treatment between the two groups. Results Before treatment, the observation group had no statistically significant difference in sTSH, FT3 and FT4 comparing with the control group（P〉0.05）. After treatment, the observation group had statistically significant difference in sTSH, FT3 and FT4 respectively as（1.98±1.13） m IU/L,（2.56±1.79） pmol/L and（12.85±3.08） pmol/L, comparing with（3.12±1.55） m IU/L,（9.33±5.28） pmol/L and（19.77±5.63） pmol/L in the control group（P〈0.05）. Conclusion Combination of methimazole and levothyroxine shows remarkable clinical effect in treating elderly Graves＇ s disease, and it is worthy of adoption.