美金刚与奥氮平治疗老年痴呆患者伴精神行为症状的临床疗效比较分析

A comparative analysis of the clinical efficacy of memantine and olanzapine in treatment of senile dementia patients with psychiatric symptoms

目的对比分析老年痴呆伴精神行为症状患者应用美金刚与奥氮平治疗的临床效果。方法将郑州市第七人民医院2014年8月—2017年8月收治的150例老年痴呆伴精神行为症状患者随机分为甲、乙、丙三组,每组各50例。甲组单纯应用美金刚治疗,乙组单纯应用奥氮平治疗,丙组应用美金刚与奥氮平联合治疗,比较3组的临床疗效。结果丙组治疗后的BEHAVE-AD评分、MOCA评分、TESS评分、QOL评分均优于甲组、乙组,差异有统计学意义(P<0.05)。结论对老年痴呆伴精神行为症状患者应用美金刚与奥氮平联合治疗,与单纯应用美金刚或奥氮平相比,疗效更为显著,临床价值更佳。

Objective To compare the clinical effects of the treatment of senile dementia with the treatment of olanzapine in patients with dementia. Methods 150 cases of senile dementia with mental behavioral symptoms admitted by the hospital from August 2014 to August 2017 were randomly divided into three groups： A,B and C,each with 50 cases. The group A was treated with usd only,and the group B was treated with olanzapine alone,and the group C was combined with olanzapine for treatment,and the clinical efficacy of three groups was compared. Results After treatment the AD ratings,MOCA score,TESS score,QOL score in group C were better than the other groups,the difference was statistically significant（ P 〈 0. 05）. Conclusion The combined treatment with olanzapine for senile dementia patients with mental behavioral symptoms is more significant and clinical value compared with the simple application of usd or olanzapine.