活血解毒中药对急性冠脉综合征患者介入术后炎症标记物和血脂的影响

Influence of Chinese medicinals with functions of activating blood and removing toxicity on inflammatory markers and blood fat in patients with acute coronary syndrome after percutaneous coronary intervention

目的观察在常规他汀药物治疗基础上加上冠心丹参滴丸+穿心莲片对急性冠脉综合征(ACS)患者介入术后血清炎症标记物和血脂的影响。方法将40例介入术后ACS患者随机分为对照组和治疗组,每组20例。对照组给予西医基础治疗加用他汀药物;治疗组,在对照组治疗基础上加用冠心丹参滴丸和穿心莲片,用药30 d。用酶联免疫吸附(ELISA)法检测用药前后血清中超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、血脂的水平以及计算血瘀证积分。结果治疗后2组患者血清hs-CRP及TNF-α与治疗前比较均有明显下降(P<0.05或P<0.01),治疗后2组间比较差异有统计学意义(P<0.01)。活血解毒中药能明显降低血清总胆固醇(TC),并可以升高血清高密度脂蛋白胆固醇(HDL-C)浓度(P<0.05);活血解毒中药组治疗后血瘀证积分较治疗前有明显降低(P<0.01)。结论活血解毒中药冠心丹参滴丸+穿心莲能进一步降低ACS患者术后血清炎性标记物hs-CRP和TNF-α水平,改善血瘀状态,并有很好的辅助综合调脂作用。

Objective To observe the influence of routine statins drugs combined with Guanxin Danshen（Coronary Salvia Root） Gutta Pills and Chuanxinlian（Andrographitis） Tablet on serum inflammatory markers and blood fat in patients with acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods ACS patient（n = 40） were randomly divided into control group and treatment group（each n = 20） after PCI. The control group was treated with basic therapy of Western medicine and statins,and treatment group was additionally given Guanxin Danshen Gutta Pills and Chuanxinlian Tablet for 30 d. The levels of serum high sensitivity C-reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α） and blood fat were detected by using ELISA,and integrals of blood stasis pattern were calculated. Results The levels of hs-CRP and TNF-α decreased significantly in 2 groups after treatment（P〈0. 05 or P〈0. 01）,and difference between 2 groups had statistical significance after treatment（P〈0. 01）. The level of serum total cholesterol（TC） decreased significantly and level of high-density lipoprotein-cholesterol（HDL-C increased in treatment group（P〈0. 05）. The integrals of blood stasis pattern decreased significantly in treatment group after treatment（P〈0. 01）. Conclusion Guanxin Danshen Gutta Pills and Chuanxinlian Tablet,with effects of activating blood and removing toxicity,can further reduce the levels of inflammatory markers,hs-CRP and TNF-α,relieve blood stasis and assist to control blood fat in patients with ACS after PCI.