摘要
免疫球蛋白（Ig）G4相关肝胆疾病是以淋巴、浆细胞性炎症为主、血清和肝／胆／胰腺组织中IgG4水平升高为特点的一组自身免疫性疾病，主要包括IgG4相关硬化性胆管炎、IgG4相关自身免疫性胰腺炎和IgG4相关自身免疫性肝炎。正确诊断有助于避免不必要的手术，早诊断早治疗可显著改善患者预后，提高患者生活质量。现对IgG4相关肝胆疾病研究中取得的进展和遇到的难点问题进行评述。
IgG4-associated hepatobiliary diseases are group of autoimmtme diseases characterized by lymphoplasmacytic infiltrates with an elevated serum IgG4 levels, affecting pancreas and biliary tract. In addition, it mainly includes IgG4-related sclerosing cholangitis, IgG4-related autoimmune pancreatitis and IgG4-related autoimmune hepatitis. An accurate diagnosis helps to avoid unnecessary surgery. Notably, an early diagnosis and treatment can improve the prognosis and enhance the quality of life. This review will focus on research advances and difficulties encountered in the study of IgG4 related hepatobiliary diseases.
作者
王绮夏
马雄
Wang Qixia;Ma Xiong(Department of Gastroenterology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2018年第6期401-403,共3页
Chinese Journal of Hepatology
基金
国家自然科学基金（81620108002,81771732,81570511,81770564）
上海市卫生计生系统优秀青年医学人才培养计划（2017YQ037）
上海市青年科技启明星计划（18QA1402700）
